Phill Hawkins

Research Summary

The programmes of work in the laboratory are currently aimed at understanding the molecular mechanisms and physiological significance of intracellular signalling networks which involve a family of enzymes called phosphoinositide 3OH-kinases (PI3Ks).

PI3Ks are now accepted to be critical regulators of numerous important and complex cell responses, including cell growth, division, survival and movement.

PI3Ks catalyse the formation of one or more critical phospholipid messenger molecules, which signal information by binding to specific domains in target proteins. Currently the best understood pathway involves the activation of Class I PI3Ks by cell surface receptors.

In recent years, the laboratory has increasingly focused on the role of PI3Ks in the signalling mechanisms which allow receptors on neutrophils (white blood cells) to control various aspects of neutrophil function.

Neutrophils are key players in the front line of our immune system, responsible primarily for the recognition and destruction of bacterial and fungal pathogens. However, they are also involved in the amplification cascades that underlie various inflammatory pathologies, e.g. Acute Respiratory Distress Syndrome (ARDS) and rheumatoid arthritis.

Latest Publications

GΒΓ IS A DIRECT REGULATOR OF ENDOGENOUS P101/P110Γ AND P84/P110Γ PI3KΓ COMPLEXES IN MOUSE NEUTROPHILS.
Rynkiewicz NK, Anderson KE, Suire S, Collins DM, Karanasios E, Vadas O, Williams R, Oxley D, Clark J, Stephens LR, Hawkins PT
Science signaling, 13, 656, 03 Nov 2020
PMID: 33144519


HOW IS THE ACYL CHAIN COMPOSITION OF PHOSPHOINOSITIDES CREATED AND DOES IT MATTER?
Barneda D, Cosulich S, Stephens L, Hawkins P
Biochemical Society transactions, 47, 5, 31 10 2019
PMID: 31657437


THE PARKINSON'S GENE PINK1 ACTIVATES AKT VIA PINK1 KINASE-DEPENDENT REGULATION OF THE PHOSPHOLIPID PI(3,4,5)P.
Furlong RM, Lindsay A, Anderson KE, Hawkins PT, Sullivan AM, O'Neill C
Journal of cell science, 1, 1477-9137, 2019
PMID: 31540955