Group Leaders

The Babraham Institute’s research focuses on understanding fundamental biology and its role in healthy ageing and disease. Our research groups form three strategic research programmes; epigenetics, signalling and immunology. You can discover more about all our research groups below.

In addition, we have a number of affiliated research groups and the Institute operates several scientific facilities. Each facility employs a specialist team with skills and expertise in key cutting-edge research techniques.
 


Christophorou lab image

Maria Christophorou

Epigenetics
How mechanisms that modulate the function of epigenetic regulators are perturbed in disease and how they may be targeted for therapeutic effect

Simon Cook

Signalling
The role of protein kinases in cellular responses to growth factors, nutrient availability or stress and damage

Anne Corcoran

Immunology
Understanding the role of chromatin and nuclear organisation in controlling gene expression during the development of the immune system

David

Della David

Signalling
Understand the molecular basis of ageing by focusing on protein aggregation - a pathological adaptation to ageing

Oliver Florey

Signalling
The role of autophagy and other cellular ‘eating’ processes in normal biology and during ageing or disease

Phill Hawkins

Signalling
The molecular mechanisms and physiological significance of signalling networks involving phosphoinositide 3-kinases (PI3Ks)

Jon Houseley

Epigenetics
The mechanisms by which cells learn to adapt and thrive in new environments

Howard

Martin Howard

Epigenetics
Using mathematical modelling to rationalise complex biological dynamics into simple underlying mechanisms

Gavin Kelsey

Epigenetics
The epigenetics of the egg and sperm and their role in carrying information between generations

Nicholas Ktistakis

Signalling
How autophagy contributes to health and healthy ageing by eliminating damage and recycling cell components

Michelle Linterman

Immunology
Understanding the changes that occur in T cells with age that contribute to the age-dependent decline in the germinal centre response

Adrian Liston

Immunology
The role of regulatory T cells in controlling and suppressing the immune system and the effect of age on these cells

McGough

Ian McGough

Signalling
How signalling pathways change in ageing organs and how such changes affect organ function

 

 

O'Donnell

Valerie O'Donnell

Signalling
The study of bioactive lipids in circulating blood cells, particularly platelets

Rayon

Teresa Rayon

Signalling/Epigenetics
How regulatory and dynamic processes control timing in development and homeostasis

Wolf Reik

Epigenetics
The role of epigenetics in cell identity and factors involved in the process of epigenetic reprogramming

Claudia Ribeiro de Almeida

Immunology
The molecular mechanisms underlying diversification of antibody genes by B cells in the immune system

 

 

 

Sarah Ross

Immunology
The effect of factors like oxygen levels on gene expression and regulation in T cells of the immune system

Peter Rugg-Gunn

Epigenetics
The epigenome in stem cells and development, and how epigenetics changes through the life course

Samant sections

Rahul Samant

Signalling
Investigating the plasticity of protein clearance pathways in young, aged, and diseased cells

Stefan Schoenfelder

Epigenetics
The functional organisation of the genome in three dimensions

Sharpe sections

Hayley Sharpe

Signalling
Understanding how the cells that make up our tissues and organs communicate

Len Stephens

Signalling
The molecular mechanisms and physiological significance of signalling networks involving phosphoinositide 3-kinases (PI3Ks)

Trefely

Sophie Trefely

Signalling/Epigenetics
Providing fundamental insights into the role of nuclear metabolism in ageing and metabolic syndrome

Martin Turner

Immunology
Gene expression and the roles of RNAs in the development and function of lymphocytes

Voigt

Philipp Voigt

Epigenetics
Understanding the molecular mechanisms that control the accurate and timely expression of genes during development

Heidi Welch

Signalling
Control of cell shape, movement, gene expression and other factors by Rac-GEF proteins