Life Sciences Research for Lifelong Health
Sharpe Lab 2019

Group Members

Dr Hayley Sharpe

view
Mr oliver Cottrell

view
Dr Gareth Fearnley

view
Dr Iain Hay

view
Ms Katherine Young

view

Latest Publications

Vismodegib resistant mutations are not selected in multifocal relapses of locally advanced basal cell carcinoma after vismodegib discontinuation.

Ighilahriz M, Benfodda M, Sharpe H

Journal of the European Academy of Dermatology and Venereology : JEADV
1468-3083: (2019)

PMID: 31187903

Grking the Smoothened signal.

Sharpe HJ, de Sauvage FJ

Science signaling
11 1937-9145: (2018)

PMID: 29438011

A new trick for an old lipid.

Sharpe H

eLife
5 2050-084X: (2016)

PMID: 27885984

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.

Bonilla X, Parmentier L, King B

Nature genetics
48 1546-1718:398-406 (2016)

PMID: 26950094

Regulation of the oncoprotein Smoothened by small molecules.

Sharpe HJ, Wang W, Hannoush RN

Nature chemical biology
11 1552-4469:246-55 (2015)

PMID: 25785427

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.

Sharpe HJ, Pau G, Dijkgraaf GJ

Cancer cell
27 1878-3686:327-41 (2015)

PMID: 25759019

Efficacy of Hedgehog pathway inhibitors in Basal cell carcinoma.

Basset-Seguin N, Sharpe HJ, de Sauvage FJ

Molecular cancer therapeutics
14 1538-8514:633-41 (2015)

PMID: 25585509

Signaling: An oxysterol ligand for Smoothened.

Sharpe HJ, de Sauvage FJ

Nature chemical biology
8 1552-4469:139-40 (2012)

PMID: 22257852

A comprehensive comparison of transmembrane domains reveals organelle-specific properties.

Sharpe HJ, Stevens TJ, Munro S

Cell
142 1097-4172:158-69 (2010)

PMID: 20603021

Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.

Strisovsky K, Sharpe HJ, Freeman M

Molecular cell
36 1097-4164:1048-59 (2009)

PMID: 20064469