Using genetically modified mice, studies at Babraham contributed to the development of drugs for one form of leukaemia, and even helped predict some of the side effects. This disorder cannot be modelled in culture or in invertebrates, which completely lack the cells affected by leukaemia.
The degeneration of nerves after injury can be delayed tenfold by a gene we identified. A key aim is to understand the mechanism so we can mimic it with a drug. Results in cell culture suggested one mechanism but studies in mice showed that this was not the full explanation, avoiding a lengthy diversion from progress towards a drug.