Latest Publications
Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels.
Riento K, Zhang Q, Clark J
PloS one
13 1932-6203:e0197401 (2018)
PMID: 29787576
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases.
Fellows R, Denizot J, Stellato C
Nature communications
9 2041-1723:105 (2018)
PMID: 29317660
PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.
Malek M, Kielkowska A, Chessa T
Molecular cell
1097-4164: (2017)
PMID: 29056325
Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations.
Huang-Doran I, Tomlinson P, Payne F
JCI insight
1 :e88766 (2016)
PMID: 27766312
Dynamics of mTORC1 activation in response to amino acids.
Manifava M, Smith M, Rotondo S
eLife
5 2050-084X: (2016)
PMID: 27725083
Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies.
Clark DE, Waszkowycz B, Wong M
Bioorganic & medicinal chemistry letters
1464-3405: (2016)
PMID: 27158141
Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Lochhead PA, Clark J, Wang LZ
Cell cycle (Georgetown, Tex.)
15 1551-4005:506-18 (2016)
PMID: 26959608
The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles.
Frej AD, Clark J, Roy CL
Molecular and cellular biology
1098-5549: (2016)
PMID: 26951199
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, Abdelmohsen K, Abe A
Autophagy
12 1554-8635:1-222 (2016)
PMID: 26799652
Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells.
Anderson KE, Juvin V, Clark J
Advances in biological regulation
2212-4934: (2015)
PMID: 26639089
Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling.
Clark J,Kay RR,Kielkowska A,Niewczas I,Fets L,Oxley D,Stephens LR,Hawkins PT
The EMBO journal
1460-2075: (2014)
PMID: 25180230
Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage.
I Angulo, O Vadas, F Garçon
Science (New York, N.Y.)
: (2013)
DOI: 10.1126/science.1243292
PMID: 24136356