Latest Publications
Translation of inhaled drug optimization strategies into clinical pharmacokinetics and pharmacodynamics using GSK2292767A, a novel inhaled PI3Kδ inhibitor.
Begg M, Edwards CD, Hamblin JN
The Journal of pharmacology and experimental therapeutics
1521-0103: (2019)
PMID: 30940692
Relationship between pharmacokinetics and pharmacodynamic responses in healthy smokers informs a once daily dosing regimen for nemiralisib.
Begg M, Wilson R, Hamblin JN
The Journal of pharmacology and experimental therapeutics
1521-0103: (2019)
PMID: 30886125
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.
Stark AK, Chandra A, Chakraborty K
Nature communications
9 2041-1723:3174 (2018)
PMID: 30093657
Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.
Rulands S, Lee HJ, Clark SJ
Cell systems
2405-4712: (2018)
PMID: 30031774
Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels.
Riento K, Zhang Q, Clark J
PloS one
13 1932-6203:e0197401 (2018)
PMID: 29787576
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases.
Fellows R, Denizot J, Stellato C
Nature communications
9 2041-1723:105 (2018)
PMID: 29317660
PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.
Malek M, Kielkowska A, Chessa T
Molecular cell
1097-4164: (2017)
PMID: 29056325
Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations.
Huang-Doran I, Tomlinson P, Payne F
JCI insight
1 :e88766 (2016)
PMID: 27766312
Dynamics of mTORC1 activation in response to amino acids.
Manifava M, Smith M, Rotondo S
eLife
5 2050-084X: (2016)
PMID: 27725083
Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies.
Clark DE, Waszkowycz B, Wong M
Bioorganic & medicinal chemistry letters
1464-3405: (2016)
PMID: 27158141
Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Lochhead PA, Clark J, Wang LZ
Cell cycle (Georgetown, Tex.)
15 1551-4005:506-18 (2016)
PMID: 26959608
The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles.
Frej AD, Clark J, Roy CL
Molecular and cellular biology
1098-5549: (2016)
PMID: 26951199