Emma DuncanEmma comes from Lincolnshire and did her degree in Human Biology at Loughborough University, followed by a masters in Molecular Biology at the University of Nottingham. She moved down to London in 2010 to become a research assistant for a couple of years at Queen Mary University of London, where she worked on the regulation of cholesterol biosynthesis with Prof Carol Shoulders.
Emma stayed at Queen Mary University for another 4 years to do a PhD with Prof Paul Chapple, where she identified that cell organelle defects and disruptions to protein homeostasis are implicated in a rare cerebellar ataxia.
She is now in her first post-doc position with Simon where she is investigating the role that DYRKs have in the regulation of the signalling scaffold protein p62/SQSTM1, which is important for autophagy, nutrient sensing and cellular stress responses.
Outside work Emma enjoys many sports including cycling, rock climbing, swimming and running.
Cook SJ, Stuart K, Gilley R
The FEBS journal
Sipthorp J, Lebraud H, Gilley R
Galloway A, Saveliev A, Łukasiak S
Science (New York, N.Y.)
352 1095-9203:453-9 (2016)
Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Lochhead PA, Clark J, Wang LZ
Cell cycle (Georgetown, Tex.)
15 1551-4005:506-18 (2016)
Branco MR, King M, Perez-Garcia V
36 1878-1551:152-63 (2016)
Caunt CJ, Sale MJ, Smith PD
Nature reviews. Cancer
15 1474-1768:577-92 (2015)
Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.
Ashford AL, Dunkley TP, Cockerill M
Cellular and molecular life sciences : CMLS
DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome.
Najas S, Arranz J, Lochhead PA
2 2352-3964:120-34 (2015)
Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast.
F Cambuli, A Murray, W Dean
26 5:5538 (2014)
Sale MJ, Cook SJ
Biochemical Society transactions
42 1470-8752:776-83 (2014)
The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G₁ cell-cycle arrest and not a direct effect on BIK protein stability.
Sale MJ, Cook SJ
The Biochemical journal
459 1470-8728:513-24 (2014)
Oncogenic K-Ras suppresses IP3-dependent Ca2+ release through remodeling of IP3Rs isoform composition and ER luminal Ca2+ levels in colorectal cancer cell lines.
C Pierro, SJ Cook, TC Foets
Journal of cell science