Richard OdleRichard grew up in Medway and found the prospect of excessive coffee consumption a suitable incentive for studying medicine at Cambridge. He is now undertaking an MB/PhD to spend some time researching with the Cookies. During his undergraduate degree, he developed an interest in cancer research and his third year project with Professor Nick Coleman investigated the signalling networks of the Human Papilloma Virus oncoproteins E6/E7. He has also researched, with Dr Gary Doherty, clinical prognostic indicators in ovarian cancer patients.
His current research focuses on the regulation of Transcription Factor EB (TFEB), in relation to ERK1/2 and the cell cycle. In his spare time, he enjoys attempting (but ultimately failing) to learn Mandarin and cooking (which tends to go wrong as well).
Richard is the first medic to undertake a PhD in the Cook lab and has taken responsibility for our health and wellbeing. He is always on hand with a warm stethoscope, suitable analgesia and an excellent bedside manner.
Kidger AM, Sipthorp J, Cook SJ
Pharmacology & therapeutics
Kidger AM, Cook SJ
The FEBS journal
285 1742-4658:42-45 (2018)
Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release.
Dautova Y, Kapustin AN, Pappert K
Journal of molecular and cellular cardiology
ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death.
Darling NJ, Balmanno K, Cook SJ
12 1932-6203:e0184907 (2017)
Cook SJ, Stuart K, Gilley R
The FEBS journal
Sipthorp J, Lebraud H, Gilley R
Galloway A, Saveliev A, Łukasiak S
Science (New York, N.Y.)
352 1095-9203:453-9 (2016)
Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Lochhead PA, Clark J, Wang LZ
Cell cycle (Georgetown, Tex.)
15 1551-4005:506-18 (2016)
Branco MR, King M, Perez-Garcia V
36 1878-1551:152-63 (2016)
Caunt CJ, Sale MJ, Smith PD
Nature reviews. Cancer
15 1474-1768:577-92 (2015)
Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.
Ashford AL, Dunkley TP, Cockerill M
Cellular and molecular life sciences : CMLS
DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome.
Najas S, Arranz J, Lochhead PA
2 2352-3964:120-34 (2015)