Life Sciences Research for Lifelong Health
Len Stephens' and Phill Hawkins' research group

Sabine Suire

Sabine did her BSc degree at the University of Angers and Masters and PhD in Cell Biology and Physiology at P et M Curie -Paris 6. Her PhD practical work took place at Nouzilly, INRA under the supervision of F Guillou and focused on the regulation of transferrin gene by the follitropin in Sertoli cells. She moved to UK for her first post-doc at the Babraham Institute (F. Stewart) for studying the role of lipocalin on early stage of mare pregnancy. At the dawn of the new millennium, she moved to the Inositide lab, where she has been working on the regulation of PI3Kγ by Ras in mouse neutrophils ever since.

Latest Publications

The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P.

Furlong RM, Lindsay A, Anderson KE

Journal of cell science
1477-9137: (2019)

PMID: 31540955

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.

Tsolakos N, Durrant TN, Chessa T

Proceedings of the National Academy of Sciences of the United States of America
115 1091-6490:12176-12181 (2018)

PMID: 30442661

Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation.

Mujalli A, Chicanne G, Bertrand-Michel J

Biochimica et biophysica acta
0006-3002: (2018)

PMID: 29902570

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ

Blood advances
1 2473-9529:918-932 (2017)

PMID: 29242851

PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.

Malek M, Kielkowska A, Chessa T

Molecular cell
1097-4164: (2017)

PMID: 29056325

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment.

Gyori D, Chessa T, Hawkins PT

Cancers
9 : (2017)

PMID: 28273837

cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.

Cerny O, Anderson KE, Stephens LR

Journal of immunology (Baltimore, Md. : 1950)
198 1550-6606:1285-1296 (2017)

PMID: 28039302

In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.

Bulley SJ, Droubi A, Clarke JH

Proceedings of the National Academy of Sciences of the United States of America
1091-6490: (2016)

PMID: 27601656