Life Sciences Research for Lifelong Health
Florey Group members

Katherine Fletcher

I studied Biochemistry at Bristol University where I developed my interest in molecular biology. After graduating I took some time to assess my next career move, taking time to volunteer in various charities and to carry out a social research project in Ghana. I returned to science when an opportunity arose for a summer internship at The Babraham Institute. This sparked my passion to begin my research career and led to a research assistant job, at the Institute, working on a full genome screen looking for autophagy enhancers and inhibitors in Nicholas Ktistakis’ lab.

I am currently funded, with a four year BBSRC studentship (starting October 2014), to carry out research in the group of Oliver Florey investigating mechanisms surrounding the autophagy related protein Atg16L1.

I am actively involved in public engagement events organised by The Babraham Institute and I have particularly enjoyed School’s day and going into local schools to deliver teaching about the science of the Institute. I look forward to being involved in further exciting opportunities to communicate science to the public and discuss the ethics and implications of our research.  
 

Latest Publications

Imaging Noncanonical Autophagy and LC3-Associated Phagocytosis in Cultured Cells.

Jacquin E, Fletcher K, Florey O

Methods in molecular biology (Clifton, N.J.)
1880 1940-6029:295-303 (2019)

PMID: 30610705

The double life of autophagy proteins.

Florey O

Nature microbiology
3 2058-5276:1334-1335 (2018)

PMID: 30478385

Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells.

Bussi C, Peralta Ramos JM, Arroyo DS

Journal of cell science
1477-9137: (2018)

PMID: 30404831

Mitosis can drive cell cannibalism through entosis.

Durgan J, Tseng YY, Hamann JC

eLife
6 2050-084X: (2017)

PMID: 28693721

PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.

Krishna S, Palm W, Lee Y

Developmental cell
38 1878-1551:536-47 (2016)

PMID: 27623384

3D correlative light and electron microscopy of cultured cells using serial blockface scanning electron microscopy.

Russell MR, Lerner TR, Burden JJ

Journal of cell science
1477-9137: (2016)

PMID: 27445312

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, Abdelmohsen K, Abe A

Autophagy
12 1554-8635:1-222 (2016)

PMID: 26799652

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation.

Florey O, Gammoh N, Kim SE

Autophagy
1554-8635:0 (2014)

PMID: 25484071

SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.

Durgan J, Tao G, Walters MS

EMBO reports
16 1469-3178:87-96 (2015)

PMID: 25394671