Katherine FletcherI studied Biochemistry at Bristol University where I developed my interest in molecular biology. After graduating I took some time to assess my next career move, taking time to volunteer in various charities and to carry out a social research project in Ghana. I returned to science when an opportunity arose for a summer internship at The Babraham Institute. This sparked my passion to begin my research career and led to a research assistant job, at the Institute, working on a full genome screen looking for autophagy enhancers and inhibitors in Nicholas Ktistakis’ lab.
I am currently funded, with a four year BBSRC studentship (starting October 2014), to carry out research in the group of Oliver Florey investigating mechanisms surrounding the autophagy related protein Atg16L1.
I am actively involved in public engagement events organised by The Babraham Institute and I have particularly enjoyed School’s day and going into local schools to deliver teaching about the science of the Institute. I look forward to being involved in further exciting opportunities to communicate science to the public and discuss the ethics and implications of our research.
Jacquin E, Fletcher K, Florey O
Methods in molecular biology (Clifton, N.J.)
1880 1940-6029:295-303 (2019)
3 2058-5276:1334-1335 (2018)
Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells.
Bussi C, Peralta Ramos JM, Arroyo DS
Journal of cell science
The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis.
Rai S, Arasteh M, Jefferson M
The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes.
Fletcher K, Ulferts R, Jacquin E
The EMBO journal
Durgan J, Tseng YY, Hamann JC
6 2050-084X: (2017)
Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation.
Jacquin E, Leclerc-Mercier S, Judon C
Krishna S, Palm W, Lee Y
38 1878-1551:536-47 (2016)
3D correlative light and electron microscopy of cultured cells using serial blockface scanning electron microscopy.
Russell MR, Lerner TR, Burden JJ
Journal of cell science
Klionsky DJ, Abdelmohsen K, Abe A
12 1554-8635:1-222 (2016)
Florey O, Gammoh N, Kim SE
Durgan J, Tao G, Walters MS
16 1469-3178:87-96 (2015)