Life Sciences Research for Lifelong Health
Wakelam group

Simon Rudge

Simon studied for his BSc Hons in Biochemistry at the University of Bristol. After completing his PhD in Biochemistry at the University of Birmingham, he took up post-doctoral positions in the USA. During this time, Simon worked on phospholipase D-mediated and phosphoinositide-regulated vesicle trafficking, using the yeast Saccharomyces cerevisae as a model organism.
Simon returned to the UK to join Professor Wakelam’s laboratory as a senior staff scientist responsible for managing the lab, and supervising students and staff, whilst continuing his research on phospholipase D and phosphoinositide-regulated cellular processes. 
Simon regularly supervises vising A level, undergraduate, work experience and Erasmus+ students, and helps lead the Institute’s delivery of an annual 8-10-week lab-based practical “Protein Challenge Project” to a local college (Cambridge Academy of Science and Technology – a University Technical College). He enjoys being an active member of the Graduate, equality4success, and Public Engagement committees

Latest Publications

A nutritional memory effect counteracts benefits of dietary restriction in old mice.

Hahn O, Drews LF, Nguyen A

Nature metabolism
1 2522-5812:1059-1073 (2019)

PMID: 31742247

Lipidomics: Current state of the art in a fast moving field.

O'Donnell VB, Ekroos K, Liebisch G

Wiley interdisciplinary reviews. Systems biology and medicine
1939-005X:e1466 (2019)

PMID: 31646749

The circadian clock components BMAL1 and REV-ERBĪ± regulate flavivirus replication.

Zhuang X, Magri A, Hill M

Nature communications
10 2041-1723:377 (2019)

PMID: 30670689

LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training.

O'Donnell VB, Dennis EA, Wakelam MJO

Science signaling
12 1937-9145: (2019)

PMID: 30622195

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism .

Witting M, Hastings J, Rodriguez N

Frontiers in molecular biosciences
5 2296-889X:96 (2018)

PMID: 30488036

3D growth of cancer cells elicits sensitivity to kinase inhibitors but not lipid metabolism modifiers.

Jones DT, Valli A, Haider S

Molecular cancer therapeutics
1538-8514: (2018)

PMID: 30478149

CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways.

Sadej R, Lu X, Turczyk L

Journal of cell science
1477-9137: (2018)

PMID: 30257985

C.Ā elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies.

Ezcurra M, Benedetto A, Sornda T

Current biology : CB
1879-0445: (2018)

PMID: 30100339

Extracellular vesicles : lipids as key components of their biogenesis and functions.

Record M, Silvente-Poirot S, Poirot M

Journal of lipid research
1539-7262: (2018)

PMID: 29764923