Claire HarwellClaire graduated from the University of Cambridge in 2013 with a BA (hons) in Natural Sciences. Specialising in Neuroscience, she developed a strong interest in diseases of the nervous system; her final year research project focusing on manipulation of the autophagy pathway as a possible treatment for dementia. As a PhD student in the Coleman lab, she is currently studying how amyloid-β and tau proteins converge to cause pathology in Alzheimer’s Disease. With particular focus on axon transport, this project aims to identify common, downstream interaction points with the hope of revealing novel therapeutic targets.
NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo.
Di Stefano M, Loreto A, Orsomando G
Current biology : CB
KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons.
Hung CO, Coleman MP
Traffic (Copenhagen, Denmark)
Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.
Harwell CS, Coleman MP
11 1750-1326:44 (2016)
Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies.
Clark DE, Waszkowycz B, Wong M
Bioorganic & medicinal chemistry letters
Hill CS, Coleman MP, Menon DK
Trends in neurosciences
39 1878-108X:311-24 (2016)
Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.
Gilley J, Ando K, Seereeram A
Neurobiology of aging
39 1558-1497:1-18 (2016)
Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.
Rodríguez-Martín T, Pooler AM, Lau DH
Neurobiology of disease
85 1095-953X:1-10 (2015)
Short-term diabetic hyperglycemia suppresses celiac ganglia neurotransmission, thereby impairing sympathetically mediated glucagon responses.
Mundinger TO, Cooper E, Coleman MP
American journal of physiology. Endocrinology and metabolism
309 1522-1555:E246-55 (2015)
Gilley J, Orsomando G, Nascimento-Ferreira I
10 2211-1247:1974-81 (2015)
Axonal transport declines with age in two distinct phases separated by a period of relative stability.
Milde S, Adalbert R, Elaman MH
Neurobiology of aging
The Axon-Protective WLD(S) Protein Partially Rescues Mitochondrial Respiration and Glycolysis After Axonal Injury.
Godzik K, Coleman MP
Journal of molecular neuroscience : MN
Di Stefano M, Nascimento-Ferreira I, Orsomando G
Cell death and differentiation