Life Sciences Research for Lifelong Health

Claire Harwell

Claire graduated from the University of Cambridge in 2013 with a BA (hons) in Natural Sciences. Specialising in Neuroscience, she developed a strong interest in diseases of the nervous system; her final year research project focusing on manipulation of the autophagy pathway as a possible treatment for dementia.  As a PhD student in the Coleman lab, she is currently studying how amyloid-β and tau proteins converge to cause pathology in Alzheimer’s Disease. With particular focus on axon transport, this project aims to identify common, downstream interaction points with the hope of revealing novel therapeutic targets.

Linkedin: http://uk.linkedin.com/pub/claire-harwell/7b/330/6b5

Latest Publications

Sarm1 Deletion, but Not Wld(S), Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy.

Gilley J, Ribchester RR, Coleman MP

Cell reports
21 2211-1247:10-16 (2017)

PMID: 28978465

NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo.

Di Stefano M, Loreto A, Orsomando G

Current biology : CB
1879-0445: (2017)

PMID: 28262487

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

Harwell CS, Coleman MP

Molecular neurodegeneration
11 1750-1326:44 (2016)

PMID: 27287430

Traumatic Axonal Injury: Mechanisms and Translational Opportunities.

Hill CS, Coleman MP, Menon DK

Trends in neurosciences
39 1878-108X:311-24 (2016)

PMID: 27040729

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.

Gilley J, Ando K, Seereeram A

Neurobiology of aging
39 1558-1497:1-18 (2016)

PMID: 26923397

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.

Rodríguez-Martín T, Pooler AM, Lau DH

Neurobiology of disease
85 1095-953X:1-10 (2015)

PMID: 26459111

Short-term diabetic hyperglycemia suppresses celiac ganglia neurotransmission, thereby impairing sympathetically mediated glucagon responses.

Mundinger TO, Cooper E, Coleman MP

American journal of physiology. Endocrinology and metabolism
309 1522-1555:E246-55 (2015)

PMID: 26037249

Absence of SARM1 rescues development and survival of NMNAT2-deficient axons.

Gilley J, Orsomando G, Nascimento-Ferreira I

Cell reports
10 2211-1247:1974-81 (2015)

PMID: 25818290

Axonal transport declines with age in two distinct phases separated by a period of relative stability.

Milde S, Adalbert R, Elaman MH

Neurobiology of aging
1558-1497: (2014)

PMID: 25443288

The Axon-Protective WLD(S) Protein Partially Rescues Mitochondrial Respiration and Glycolysis After Axonal Injury.

Godzik K, Coleman MP

Journal of molecular neuroscience : MN
1559-1166: (2014)

PMID: 25352062