Babraham Institute

Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.

Suire S, Baltanas FC, Segonds-Pichon A

Journal of leukocyte biology
1938-3673: (2019)

PMID: 30720883

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.

Tsolakos N, Durrant TN, Chessa T

Proceedings of the National Academy of Sciences of the United States of America
115 1091-6490:12176-12181 (2018)

PMID: 30442661

Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.

Koohy H, Bolland DJ, Matheson LS

Genome biology
19 1474-760X:126 (2018)

PMID: 30180872

Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation.

Mujalli A, Chicanne G, Bertrand-Michel J

Biochimica et biophysica acta
0006-3002: (2018)

PMID: 29902570

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.

Gyori D, Lim EL, Grant FM

JCI insight
3 2379-3708: (2018)

PMID: 29875321

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ

Blood advances
1 2473-9529:918-932 (2017)

PMID: 29242851

PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.

Malek M, Kielkowska A, Chessa T

Molecular cell
1097-4164: (2017)

PMID: 29056325

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment.

Gyori D, Chessa T, Hawkins PT

Cancers
9 : (2017)

PMID: 28273837

cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.

Cerny O, Anderson KE, Stephens LR

Journal of immunology (Baltimore, Md. : 1950)
198 1550-6606:1285-1296 (2017)

PMID: 28039302

In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.

Bulley SJ, Droubi A, Clarke JH

Proceedings of the National Academy of Sciences of the United States of America
1091-6490: (2016)

PMID: 27601656

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells.

Ross SH, Rollings C, Anderson KE

Immunity
1097-4180: (2016)

PMID: 27566939

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.

Houslay DM, Anderson KE, Chessa T

Science signaling
9 1937-9145:ra82 (2016)

PMID: 27531651

Life Sciences Research for Lifelong Health