Babraham Institute

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment.

Gyori D, Chessa T, Hawkins PT

Cancers
9 : (2017)

PMID: 28273837

In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.

Bulley SJ, Droubi A, Clarke JH

Proceedings of the National Academy of Sciences of the United States of America
1091-6490: (2016)

PMID: 27601656

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells.

Ross SH, Rollings C, Anderson KE

Immunity
1097-4180: (2016)

PMID: 27566939

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.

Houslay DM, Anderson KE, Chessa T

Science signaling
9 1937-9145:ra82 (2016)

PMID: 27531651

The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles.

Frej AD, Clark J, Roy CL

Molecular and cellular biology
1098-5549: (2016)

PMID: 26951199

Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways.

Hawkins PT, Stephens LR

Biochemical Society transactions
44 1470-8752:307-14 (2016)

PMID: 26862220

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity.

Alliouachene S, Bilanges B, Chicanne G

Cell reports
13 2211-1247:1881-94 (2015)

PMID: 26655903

Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells.

Anderson KE, Juvin V, Clark J

Advances in biological regulation
2212-4934: (2015)

PMID: 26639089

Localizing the lipid products of PI3Kγ in neutrophils.

Norton L, Lindsay Y, Deladeriere A

Advances in biological regulation
2212-4934: (2015)

PMID: 26596865

The cytotoxic T cell proteome and its shaping by the kinase mTOR.

Hukelmann JL, Anderson KE, Sinclair LV

Nature immunology
1529-2916: (2015)

PMID: 26551880

Perturbations of PIP3 signalling trigger a global remodelling of mRNA landscape and reveal a transcriptional feedback loop.

Kiselev VY, Juvin V, Malek M

Nucleic acids research
1362-4962: (2015)

PMID: 26464442

The regulatory subunits of PI3Kγ control distinct neutrophil responses.

Deladeriere A, Gambardella L, Pan D

Science signaling
8 1937-9145:ra8 (2015)

PMID: 25605974

Life Sciences Research for Lifelong Health