Life Sciences Research for Lifelong Health

Jonathan Coates

I have recently completed my PhD investigating the existence and function of macrophage subtypes in Drosophila. My interests are varied but focus primarily around immune cell biology, particularly the role of metabolism and hypoxia.

I completed my undergraduate degree in Biomedical Science at Northumbria University and then pursued an MRes in Immunology at Newcastle University. My MRes involved investigating fibroblast subtypes in synovial fibroblasts. Following this I completed my PhD in the Evans and Zeidler labs at Sheffield University in 2019. This left me with a wide range of microscopy skills and a foundation in innate immunology.

I have recently joined Sarah as a post-doc for the new challenges of sequencing and the adaptive immune system. I am investigating the genetic and epigenetic responses to hypoxia in CD8+ T cells.

Latest Publications

Signaling and Function of Interleukin-2 in T Lymphocytes.

Ross SH, Cantrell DA

Annual review of immunology
36 1545-3278:411-433 (2018)

PMID: 29677473

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment-sensing programs.

Rollings CM, Sinclair LV, Brady HJM

Science signaling
11 1937-9145: (2018)

PMID: 29666307

Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29.

Post A, Pannekoek WJ, Ross SH

Proceedings of the National Academy of Sciences of the United States of America
110 1091-6490:11427-32 (2013)

PMID: 23798437

Ezrin is required for efficient Rap1-induced cell spreading.

Ross SH, Post A, Raaijmakers JH

Journal of cell science
124 1477-9137:1808-18 (2011)

PMID: 21540295

Differential redox regulation within the PTP superfamily.

Ross SH, Lindsay Y, Safrany ST

Cellular signalling
19 0898-6568:1521-30 (2007)

PMID: 17346927

Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.

Downes CP, Ross S, Maccario H

Advances in enzyme regulation
47 0065-2571:184-94 (2007)

PMID: 17343901

Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN.

Downes CP, Perera N, Ross S

Biochemical Society symposium
0067-8694:69-80 (2007)

PMID: 17233581

Redox regulation of phosphatase function.

Leslie NR, Lindsay Y, Ross SH

Biochemical Society transactions
32 0300-5127:1018-20 (2004)

PMID: 15506952