Life Sciences Research for Lifelong Health
Roychoudhuri Group members

Tihomir Todorov

At present, Tihomir is a visiting student at Rahul Roychoudhuri`s group supported by the Erasmus+ traineeship program. Tihomir acquired a B.Sc. in Molecular biology in 2016 at Sofia University, Bulgaria. His thesis in the field of plant molecular biology focused on the salinity response of common wheat (Tr. aestivum) and the ancient cereal cultivars oriental wheat (Tr. turanicum) and spelt (Tr. spelta). Earning a scholarship from the Amgen Scholars Program in 2015, he received the opportunity to conduct research on chaperone-assisted protein folding at Max-Planck Institute of Biochemistry, Munich, Germany.

His path took him to Ludwig-Maximilian University (LMU) in Munich, Germany, where Tihomir has been pursuing a M. Sc. in Biochemistry. During his time at LMU, he studied innate immune mechanisms and carried out research in translational cancer immunology with focus on immune checkpoint blockade therapy.

Tihomir’s work aims at the Babraham Institute aims at elucidating how transcription factors control regulatory T cell (Treg) differentiation and function.

Latest Publications

Paths to expansion: Differential requirements of IRF4 in CD8 T-cell expansion driven by antigen and homeostatic cytokines.

Lugli E, Brummelman J, Pilipow K

European journal of immunology
48 1521-4141:1281-1284 (2018)

PMID: 30133745

Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors.

Miura Y, Morooka M, Sax N

Journal of immunology (Baltimore, Md. : 1950)
1550-6606: (2018)

PMID: 29540581

Epigenetic control of CD8+ T cell differentiation.

Henning AN, Roychoudhuri R, Restifo NP

Nature reviews. Immunology
1474-1741: (2018)

PMID: 29379213

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali B, Grönholm J, Vandrovcova J

Nature immunology
1529-2916: (2017)

PMID: 28530713

BACH transcription factors in innate and adaptive immunity.

Igarashi K, Kurosaki T, Roychoudhuri R

Nature reviews. Immunology
1474-1741: (2017)

PMID: 28461702

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Eil R, Vodnala SK, Clever D

537 1476-4687:539-543 (2016)

PMID: 27626381

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

Clever D, Roychoudhuri R, Constantinides MG

166 1097-4172:1117-1131.e14 (2016)

PMID: 27565342

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.

Roychoudhuri R, Clever D, Li P

Nature immunology
1529-2916: (2016)

PMID: 27158840

The transcription factor BACH2 promotes tumor immunosuppression.

Roychoudhuri R, Eil RL, Clever D

The Journal of clinical investigation
1558-8238: (2016)

PMID: 26731475