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Francis Grant
Francis graduated from the University of East Anglia in 2011 with a B.Sc. in Biological Sciences with a year in Industry. His thesis explored how key intracellular signalling mechanisms control T cell function during adaptive immune responses. His subsequent work in the Industrial sector contributed to the development of novel therapeutics that target T cell signalling mechanisms to treat autoimmune disease. Francis is now undertaking a PhD in Rahul Roychoudhuri’s lab, exploring how transcription factors cooperate to control the stability and function of regulatory T cells.Latest Publications
Paths to expansion: Differential requirements of IRF4 in CD8 T-cell expansion driven by antigen and homeostatic cytokines.
Lugli E, Brummelman J, Pilipow K
European journal of immunology
48 1521-4141:1281-1284 (2018)
PMID: 30133745
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
Gyori D, Lim EL, Grant FM
JCI insight
3 2379-3708: (2018)
PMID: 29875321
Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.
Lim EL, Cugliandolo FM, Rosner DR
JCI insight
3 2379-3708: (2018)
PMID: 29875319
Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors.
Miura Y, Morooka M, Sax N
Journal of immunology (Baltimore, Md. : 1950)
1550-6606: (2018)
PMID: 29540581
Epigenetic control of CD8+ T cell differentiation.
Henning AN, Roychoudhuri R, Restifo NP
Nature reviews. Immunology
1474-1741: (2018)
PMID: 29379213
BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.
Afzali B, Grönholm J, Vandrovcova J
Nature immunology
1529-2916: (2017)
PMID: 28530713
BACH transcription factors in innate and adaptive immunity.
Igarashi K, Kurosaki T, Roychoudhuri R
Nature reviews. Immunology
1474-1741: (2017)
PMID: 28461702
Ionic immune suppression within the tumour microenvironment limits T cell effector function.
Eil R, Vodnala SK, Clever D
Nature
537 1476-4687:539-543 (2016)
PMID: 27626381
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Clever D, Roychoudhuri R, Constantinides MG
Cell
166 1097-4172:1117-1131.e14 (2016)
PMID: 27565342
Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes.
Nasrallah R, Fast EM, Solaimani P
Blood
1528-0020: (2016)
PMID: 27554085
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Roychoudhuri R, Clever D, Li P
Nature immunology
1529-2916: (2016)
PMID: 27158840
The transcription factor BACH2 promotes tumor immunosuppression.
Roychoudhuri R, Eil RL, Clever D
The Journal of clinical investigation
1558-8238: (2016)
PMID: 26731475