Life Sciences Research for Lifelong Health

David Posner

I grew up in Morelia, a fairly large city in central-west Mexico. In 2012 I moved to the San Francisco Bay in California, where I began my career in biomedical research. I got the wonderful opportunity to spend a few summers working in the lab of Noelle L'Etoile at UCSF studying the role of argonaute protein HRDE-1 in the olfactory adaptation of C. elegans progeny. After my second year of college, I was a fellow in an MD-PhD summer program at Dartmouth College, where I enjoyed a fantastic experience working in David Leib's lab investigating the infiltration of IgG into the Trigeminal Ganglion during a Herpes Simplex Virus infection, where I was a co-author.

I graduated with a bachelor's in Biochemistry from Siena College, about 3 hours north of Manhattan, but I worked in a natural products chemistry lab. Alongside my mentor, Stephen Deyrup, I developed assays to study antibiotic production from live fungi. Other projects in the lab included the identification of chemical defence molecules called lucibufagins in several species of fireflies using 2D NMR techniques, HPLC and LCMS.

Now, I have the pleasure of being in Adrian Liston's lab where I am working toward my PhD. I currently study a special subset of regulatory T cells (Treg) that are found in the brain. Normally, Tregs are heavily involved in immunosuppression of effector T cells in order to prevent autoimmune disease. Recently, a lot of the efforts in the field have been focused on describing the specialized function of Tregs in various tissues such as the skin, the gut, lungs and muscle (to name a few). In our lab, we are hoping to elucidate the function of brain Tregs during development, and how they help maintain, or fail to do so, in homeostasis and disease.

Latest Publications

Stem-cell-derived human microglia transplanted in mouse brain to study human disease.

Mancuso R, Van Den Daele J, Fattorelli N

Nature neuroscience
1546-1726: (2019)

PMID: 31659342

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.

Habets RA, de Bock CE, Serneels L

Science translational medicine
11 1946-6242: (2019)

PMID: 31142678

Inborn errors of immunity: single mutations unravel mechanisms of immune disease.

Liston A, Humblet-Baron S

Immunology and cell biology
1440-1711: (2019)

PMID: 30942931

The Aire family expands.

Liston A, Dooley J

The Journal of experimental medicine
1540-9538: (2019)

PMID: 30923044

Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes.

Van Nieuwenhove E, Lagou V, Van Eyck L

Annals of the rheumatic diseases
1468-2060: (2019)

PMID: 30862608

Prospective study evaluating immune-mediated mechanisms and predisposing factors underlying persistent postinfectious abdominal complaints.

Florens MV, Van Wanrooy S, Dooley J

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
31 1365-2982:e13542 (2019)

PMID: 30657233

IFN-γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis.

Humblet-Baron S, Franckaert D, Dooley J

The Journal of allergy and clinical immunology
1097-6825: (2018)

PMID: 30578871

NFIL3 mutations alter immune homeostasis and sensitise for arthritis pathology.

Schlenner S, Pasciuto E, Lagou V

Annals of the rheumatic diseases
78 1468-2060:342-349 (2019)

PMID: 30552177

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators.

Lagou V, Garcia-Perez JE, Smets I

Cell reports
25 2211-1247:798-810.e6 (2018)

PMID: 30332657