David PosnerI grew up in Morelia, a fairly large city in central-west Mexico. In 2012 I moved to the San Francisco Bay in California, where I began my career in biomedical research. I got the wonderful opportunity to spend a few summers working in the lab of Noelle L'Etoile at UCSF studying the role of argonaute protein HRDE-1 in the olfactory adaptation of C. elegans progeny. After my second year of college, I was a fellow in an MD-PhD summer program at Dartmouth College, where I enjoyed a fantastic experience working in David Leib's lab investigating the infiltration of IgG into the Trigeminal Ganglion during a Herpes Simplex Virus infection, where I was a co-author.
I graduated with a bachelor's in Biochemistry from Siena College, about 3 hours north of Manhattan, but I worked in a natural products chemistry lab. Alongside my mentor, Stephen Deyrup, I developed assays to study antibiotic production from live fungi. Other projects in the lab included the identification of chemical defence molecules called lucibufagins in several species of fireflies using 2D NMR techniques, HPLC and LCMS.
Now, I have the pleasure of being in Adrian Liston's lab where I am working toward my PhD. I currently study a special subset of regulatory T cells (Treg) that are found in the brain. Normally, Tregs are heavily involved in immunosuppression of effector T cells in order to prevent autoimmune disease. Recently, a lot of the efforts in the field have been focused on describing the specialized function of Tregs in various tissues such as the skin, the gut, lungs and muscle (to name a few). In our lab, we are hoping to elucidate the function of brain Tregs during development, and how they help maintain, or fail to do so, in homeostasis and disease.
Mancuso R, Van Den Daele J, Fattorelli N
Longitudinal In Vivo Assessment of Host-Microbe Interactions in a Murine Model of Pulmonary Aspergillosis.
Saini S, Poelmans J, Korf H
20 2589-0042:184-194 (2019)
Habets RA, de Bock CE, Serneels L
Science translational medicine
11 1946-6242: (2019)
Liston A, Humblet-Baron S
Immunology and cell biology
Liston A, Dooley J
The Journal of experimental medicine
Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes.
Van Nieuwenhove E, Lagou V, Van Eyck L
Annals of the rheumatic diseases
Prospective study evaluating immune-mediated mechanisms and predisposing factors underlying persistent postinfectious abdominal complaints.
Florens MV, Van Wanrooy S, Dooley J
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
31 1365-2982:e13542 (2019)
Humblet-Baron S, Franckaert D, Dooley J
The Journal of allergy and clinical immunology
Schlenner S, Pasciuto E, Lagou V
Annals of the rheumatic diseases
78 1468-2060:342-349 (2019)
A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease.
Van Horebeek L, Hilven K, Mallants K
Human molecular genetics
Murine myeloproliferative disorder as a consequence of impaired collaboration between dendritic cells and CD4 T cells.
Humblet-Baron S, Barber JS, Roca CP
133 1528-0020:319-330 (2019)
Lagou V, Garcia-Perez JE, Smets I
25 2211-1247:798-810.e6 (2018)