Life Sciences Research for Lifelong Health

Carlos Roca

I am a scientist who does research on biostatistics and bioinformatics, to answer questions in systems biology and biomedicine. Previously, I worked as a software consultant for private companies in the sectors of finance, communications, and aeronautics.

I started to work at research institutions in 2004, and I completed a Ph.D. in applied mathematics in 2009. Initially, my scientific work concerned computational models inspired by evolutionary game theory, addressing the problems of cooperation and altruism. Then, I moved to do research more grounded on empirical data and closer to molecular and cell biology.

I work now in direct collaboration with biologists, embedded in an immunology lab, aiming to provide reliable methods of data analysis. I have worked extensively in the study of differential gene expression and pathway expression. My current focus is on analyzing data and developing methods for flow cytometry and single-cell sequencing assays, in studies on basic and applied immunology.

Latest Publications

Stem-cell-derived human microglia transplanted in mouse brain to study human disease.

Mancuso R, Van Den Daele J, Fattorelli N

Nature neuroscience
1546-1726: (2019)

PMID: 31659342

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.

Habets RA, de Bock CE, Serneels L

Science translational medicine
11 1946-6242: (2019)

PMID: 31142678

Inborn errors of immunity: single mutations unravel mechanisms of immune disease.

Liston A, Humblet-Baron S

Immunology and cell biology
1440-1711: (2019)

PMID: 30942931

The Aire family expands.

Liston A, Dooley J

The Journal of experimental medicine
1540-9538: (2019)

PMID: 30923044

Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes.

Van Nieuwenhove E, Lagou V, Van Eyck L

Annals of the rheumatic diseases
1468-2060: (2019)

PMID: 30862608

Prospective study evaluating immune-mediated mechanisms and predisposing factors underlying persistent postinfectious abdominal complaints.

Florens MV, Van Wanrooy S, Dooley J

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
31 1365-2982:e13542 (2019)

PMID: 30657233

IFN-γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis.

Humblet-Baron S, Franckaert D, Dooley J

The Journal of allergy and clinical immunology
1097-6825: (2018)

PMID: 30578871

NFIL3 mutations alter immune homeostasis and sensitise for arthritis pathology.

Schlenner S, Pasciuto E, Lagou V

Annals of the rheumatic diseases
78 1468-2060:342-349 (2019)

PMID: 30552177

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators.

Lagou V, Garcia-Perez JE, Smets I

Cell reports
25 2211-1247:798-810.e6 (2018)

PMID: 30332657