Life Sciences Research for Lifelong Health

Melanie Eckersley-Maslin

Short Biography:
 
2014 - current: Postdoctoral Research Fellow, Babraham Institute, Cambridge UK (funded by EMBO LT Fellowship and Marie Curie Individual Fellowship) and Sackler Research Fellow, Christ's College, The University of Cambridge www.christs.cam.ac.uk/content/dr-melanie-eckersley-maslin
2008-2014: PhD in Molecular Biology, The Watson School of Biological Sciences, Cold Spring Harbor Laboratory, USA
2004-2007: Bachelor of Advanced Science (Honours, University Medal), The University of Sydney, Australia
 
Research Interests:
 
My research passion surrounds the very early stages of mammalian embryonic development, one of the most dramatic chromatin and epigenetic transformations in an organism's life. Following fertilisation, the embryonic genome must be correctly remodelled and transcriptionally activated to produce a totipotent embryo. My research aims to understand the epigenetic contribution of these developmental events, including how zygotic genome activation is regulated at the molecular level, and the contribution of epigenetic and transcriptional heterogeneity between single cells in cell fate decisions.



Latest Publications

Voices in methods development.

Anikeeva P, Boyden E, Brangwynne C

Nature methods
16 1548-7105:945-951 (2019)

PMID: 31562479

Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells.

Hernando-Herraez I, Evano B, Stubbs T

Nature communications
10 2041-1723:4361 (2019)

PMID: 31554804

Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.

Stuart HT, Stirparo GG, Lohoff T

Cell stem cell
1875-9777: (2019)

PMID: 31422912

Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1.

Martin-Herranz DE, Aref-Eshghi E, Bonder MJ

Genome biology
20 1474-760X:146 (2019)

PMID: 31409373

Establishment of porcine and human expanded potential stem cells.

Gao X, Nowak-Imialek M, Chen X

Nature cell biology
21 1476-4679:687-699 (2019)

PMID: 31160711

TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn.

Montalbán-Loro R, Lozano-Ureña A, Ito M

Nature communications
10 2041-1723:1726 (2019)

PMID: 30979904

A single-cell molecular map of mouse gastrulation and early organogenesis.

Pijuan-Sala B, Griffiths JA, Guibentif C

Nature
1476-4687: (2019)

PMID: 30787436

Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.

Eckersley-Maslin M, Alda-Catalinas C, Blotenburg M

Genes & development
33 1549-5477:194-208 (2019)

PMID: 30692203

Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution.

Messmer T, von Meyenn F, Savino A

Cell reports
26 2211-1247:815-824.e4 (2019)

PMID: 30673604

The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome.

Gdula MR, Nesterova TB, Pintacuda G

Nature communications
10 2041-1723:30 (2019)

PMID: 30604745