Life Sciences Research for Lifelong Health

Melanie Eckersley-Maslin

Short Biography:
 
2014 - current: Postdoctoral Research Fellow, Babraham Institute, Cambridge UK (funded by EMBO LT Fellowship and Marie Curie Individual Fellowship) and Sackler Research Fellow, Christ's College, The University of Cambridge www.christs.cam.ac.uk/content/dr-melanie-eckersley-maslin
2008-2014: PhD in Molecular Biology, The Watson School of Biological Sciences, Cold Spring Harbor Laboratory, USA
2004-2007: Bachelor of Advanced Science (Honours, University Medal), The University of Sydney, Australia
 
Research Interests:
 
My research passion surrounds the very early stages of mammalian embryonic development, one of the most dramatic chromatin and epigenetic transformations in an organism's life. Following fertilisation, the embryonic genome must be correctly remodelled and transcriptionally activated to produce a totipotent embryo. My research aims to understand the epigenetic contribution of these developmental events, including how zygotic genome activation is regulated at the molecular level, and the contribution of epigenetic and transcriptional heterogeneity between single cells in cell fate decisions.



Latest Publications

Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity.

Hahn O, Stubbs TM, Reik W

PLoS genetics
14 1553-7404:e1007766 (2018)

PMID: 30462643

Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development.

Boroviak T, Stirparo GG, Dietmann S

Development (Cambridge, England)
145 1477-9129: (2018)

PMID: 30413530

5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells.

Raiber EA, Portella G, Martínez Cuesta S

Nature chemistry
1755-4349: (2018)

PMID: 30349137

Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition.

Sarker G, Berrens R, von Arx J

Translational psychiatry
8 2158-3188:195 (2018)

PMID: 30315171

Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.

Rulands S, Lee HJ, Clark SJ

Cell systems
2405-4712: (2018)

PMID: 30031774

Defective germline reprogramming rewires the spermatogonial transcriptome.

VasiliauskaitÄ— L, Berrens RV, Ivanova I

Nature structural & molecular biology
25 1545-9985:394-404 (2018)

PMID: 29728652

Dynamics of the epigenetic landscape during the maternal-to-zygotic transition.

Eckersley-Maslin MA, Alda-Catalinas C, Reik W

Nature reviews. Molecular cell biology
1471-0080: (2018)

PMID: 29686419

Correction: Epigenetic resetting of human pluripotency (doi:10.1242/dev.146811).

Guo G, von Meyenn F, Rostovskaya M

Development (Cambridge, England)
145 1477-9129: (2018)

PMID: 29669738

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.

Clark SJ, Argelaguet R, Kapourani CA

Nature communications
9 2041-1723:781 (2018)

PMID: 29472610

Science Forum: The Human Cell Atlas.

Regev A, Teichmann SA, Lander ES

eLife
6 2050-084X: (2017)

PMID: 29206104