Rebecca BerrensShort Biography
2013 - current: PhD student at Cambridge University, Babraham Institute (Funded by Gates Cambridge scholarship)
2010 - 2012: Master in Molecular Biotechnology at Heidelberg University
2007 - 2010: Bachelor in Molecular Cell Biology at Heidelberg University
Research Interests and Activities
I am interested in transposon regulation and its role in epigenetic reprogramming during early embryonic development in mammals.
Transposons are known to be highly guarded by DNA methylation in somatic cells, though histone modifications and small RNAs have also been found to play a role in keeping these repeat elements in check.
My work focuses on the effect of the genome wide erasure of epigenetic marks in the early embryo, on transposon activity. Specifically, the dynamics and interplay between DNA methylation, histone modifications and, my main area of interest- small RNAs, which lead to the silencing of transposons.
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.
Clark SJ, Argelaguet R, Kapourani CA
9 2041-1723:781 (2018)
Regev A, Teichmann SA, Lander ES
6 2050-084X: (2017)
Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.
Aarts M, Georgilis A, Beniazza M
Genes & development
An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells.
Berrens RV, Andrews S, Spensberger D
Cell stem cell
21 1875-9777:694-703.e7 (2017)
Martin-Herranz DE, Ribeiro AJM, Krueger F
Nucleic acids research
Yang J, Ryan DJ, Wang W
Kelsey G, Stegle O, Reik W
Science (New York, N.Y.)
358 1095-9203:69-75 (2017)
Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation.
Mohammed H, Hernando-Herraez I, Savino A
20 2211-1247:1215-1228 (2017)
Guo G, von Meyenn F, Rostovskaya M
Development (Cambridge, England)
144 1477-9129:2748-2763 (2017)
Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.
Kirschner K, Chandra T, Kiselev V
19 2211-1247:1503-1511 (2017)
Vasiliauskaitė L, Vitsios D, Berrens RV
Nature structural & molecular biology
Stubbs TM, Bonder MJ, Stark AK
18 1474-760X:68 (2017)