Life Sciences Research for Lifelong Health

Claudia Semprich

Claudi was awarded her Ph.D. in 2016 after researching the “Regulation of Polycomb Repressive Complexes at the Neural Differentiation Gene Pax6” under the supervision of Prof. Kate Storey in Dundee. Before that, Claudi obtained her Masters in Molecular and Cellular Biology from the University of Potsdam, studying the role of histone modifications in co-transcriptional splicing.

Claudi enjoys hiking in the hills – not such an easy hobby to maintain after moving from Dundee to Cambridge…  Funded by a BBSRC ISPG, Claudi joined the Babraham Institute in 2018 to study the mechanisms controlling epigenetic heterogeneity and lineage-priming in human pluripotency.

Latest Publications

Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.

Rulands S, Lee HJ, Clark SJ

Cell systems
2405-4712: (2018)

PMID: 30031774

Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.

Choy MK, Javierre BM, Williams SG

Nature communications
9 2041-1723:2526 (2018)

PMID: 29955040

Identifying Human Naïve Pluripotent Stem Cells - Evaluating State-Specific Reporter Lines and Cell-Surface Markers.

Collier AJ, Rugg-Gunn PJ

BioEssays : news and reviews in molecular, cellular and developmental biology
1521-1878:e1700239 (2018)

PMID: 29574793

Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.

Freire-Pritchett P, Schoenfelder S, Várnai C

eLife
6 2050-084X: (2017)

PMID: 28332981

Derivation and Culture of Epiblast Stem Cell (EpiSC) Lines.

Rugg-Gunn P

Cold Spring Harbor protocols
2017 1559-6095:pdb.prot093971 (2017)

PMID: 28049783