Claudia SemprichClaudi was awarded her Ph.D. in 2016 after researching the “Regulation of Polycomb Repressive Complexes at the Neural Differentiation Gene Pax6” under the supervision of Prof. Kate Storey in Dundee. Before that, Claudi obtained her Masters in Molecular and Cellular Biology from the University of Potsdam, studying the role of histone modifications in co-transcriptional splicing.
Claudi enjoys hiking in the hills – not such an easy hobby to maintain after moving from Dundee to Cambridge… Funded by a BBSRC ISPG, Claudi joined the Babraham Institute in 2018 to study the mechanisms controlling epigenetic heterogeneity and lineage-priming in human pluripotency.
Rulands S, Lee HJ, Clark SJ
Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.
Choy MK, Javierre BM, Williams SG
9 2041-1723:2526 (2018)
Identifying Human Naïve Pluripotent Stem Cells - Evaluating State-Specific Reporter Lines and Cell-Surface Markers.
Collier AJ, Rugg-Gunn PJ
BioEssays : news and reviews in molecular, cellular and developmental biology
Long-Range Enhancer Interactions Are Prevalent in Mouse Embryonic Stem Cells and Are Reorganized upon Pluripotent State Transition.
Novo CL, Javierre BM, Cairns J
22 2211-1247:2615-2627 (2018)
Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline.
Lupo G, Nisi PS, Esteve P
Naive pluripotent stem cells as a model for studying human developmental epigenomics: opportunities and limitations.
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.
Andrews PW, Ben-David U, Benvenisty N
Stem cell reports
9 2213-6711:1-4 (2017)
Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis.
Carucci N, Cacci E, Nisi PS
Royal Society open science
4 :160913 (2017)
Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States.
Collier AJ, Panula SP, Schell JP
Cell stem cell
Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.
Freire-Pritchett P, Schoenfelder S, Várnai C
6 2050-084X: (2017)
DNA methylation is dispensable for changes in global chromatin architecture but required for chromocentre formation in early stem cell differentiation.
Hassan-Zadeh V, Rugg-Gunn P, Bazett-Jones DP
Cold Spring Harbor protocols
2017 1559-6095:pdb.prot093971 (2017)