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Charlene Fabian
Charlene was awarded an MSci in Molecular and Cellular Biology by the University of Glasgow in 2016. As part of her course, Charlene undertook a one-year research placement within the Refractory, Respiratory and Inflammation Discover Performance Unit of GSK, where she was involved in target identification.Charlene started her PhD at the Babraham Institute in October 2016 and is funded by an MRC Industrial CASE Studentship. In collaboration with DefiniGEN, Charlene will investigate the role of epigenetic processes in the specification of pancreatic cells from human pluripotent stem cells.
Latest Publications
Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.
Rulands S, Lee HJ, Clark SJ
Cell systems
2405-4712: (2018)
PMID: 30031774
Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.
Choy MK, Javierre BM, Williams SG
Nature communications
9 2041-1723:2526 (2018)
PMID: 29955040
Identifying Human Naïve Pluripotent Stem Cells - Evaluating State-Specific Reporter Lines and Cell-Surface Markers.
Collier AJ, Rugg-Gunn PJ
BioEssays : news and reviews in molecular, cellular and developmental biology
1521-1878:e1700239 (2018)
PMID: 29574793
Long-Range Enhancer Interactions Are Prevalent in Mouse Embryonic Stem Cells and Are Reorganized upon Pluripotent State Transition.
Novo CL, Javierre BM, Cairns J
Cell reports
22 2211-1247:2615-2627 (2018)
PMID: 29514091
Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline.
Lupo G, Nisi PS, Esteve P
Aging cell
1474-9726: (2018)
PMID: 29504228
Naive pluripotent stem cells as a model for studying human developmental epigenomics: opportunities and limitations.
Rugg-Gunn PJ
Epigenomics
1750-192X: (2017)
PMID: 29106295
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.
Andrews PW, Ben-David U, Benvenisty N
Stem cell reports
9 2213-6711:1-4 (2017)
PMID: 28700896
Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis.
Carucci N, Cacci E, Nisi PS
Royal Society open science
4 :160913 (2017)
PMID: 28484611
Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States.
Collier AJ, Panula SP, Schell JP
Cell stem cell
1875-9777: (2017)
PMID: 28343983
Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.
Freire-Pritchett P, Schoenfelder S, Várnai C
eLife
6 2050-084X: (2017)
PMID: 28332981
DNA methylation is dispensable for changes in global chromatin architecture but required for chromocentre formation in early stem cell differentiation.
Hassan-Zadeh V, Rugg-Gunn P, Bazett-Jones DP
Chromosoma
1432-0886: (2017)
PMID: 28084535
Derivation and Culture of Epiblast Stem Cell (EpiSC) Lines.
Rugg-Gunn P
Cold Spring Harbor protocols
2017 1559-6095:pdb.prot093971 (2017)
PMID: 28049783