Life Sciences Research for Lifelong Health

Group Members

PeterOur group is housed within a large open plan lab that is shared with all members of the Epigenetics Programme. The open setting establishes an exciting dynamic between research groups, often leading to collaborations, training in new methods and interesting discussions. Weekly departmental meetings and seminars reinforce these close interactions.

Outside of Epigenetics, we collaborate closely with several groups within the Lymphocyte and Signalling Programmes, with a particular focus on potential interactions between signalling pathways and epigenetic processes. Our research also benefits greatly from the excellent facilities at the Babraham Institute, with state-of-the-art genomics, flow cytometry, imaging, mass spectrometry and bioinformatics.

​We maintain close links with the University of Cambridge, with affiliations at the WT-MRC Cambridge Stem Cell Institute (www.stemcells.cam.ac.uk) and the Centre for Trophoblast Research (www.trophoblast.cam.ac.uk). Our group is also a member of the EpiGeneSys Network, which is focused on epigenetics and systems biology.
 

Peter's Career

Peter joined the Babraham Institute in 2011 as a Wellcome Trust Research Career Development Fellow. Peter trained in the laboratories of Roger Pedersen (University of Cambridge) and Janet Rossant (The Hospital for Sick Children, Toronto) where he developed his interest in understanding the epigenetic regulation of stem cells and lineage specification. Peter's research is currently focused on understanding the epigenetic mechanisms that control developmental and stem cell regulation. 

Peter is also involved in the societal impact of stem cell research – working with artists, legal scholars and policy makers to examine the complex ethical and social issues surrounding new biotechnologies such as gene editing in stem cells.


 
Dr Peter Rugg-Gunn

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Mr Adam Bendall

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Amanda Collier

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Miss Charlene Fabian

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Mr Andrew Malcolm

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Ms Paola Nisi

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Dr Clara Novo

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Dr Claudia Semprich

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Latest Publications

Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.

Rulands S, Lee HJ, Clark SJ

Cell systems
2405-4712: (2018)

PMID: 30031774

Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.

Choy MK, Javierre BM, Williams SG

Nature communications
9 2041-1723:2526 (2018)

PMID: 29955040

Identifying Human Naïve Pluripotent Stem Cells - Evaluating State-Specific Reporter Lines and Cell-Surface Markers.

Collier AJ, Rugg-Gunn PJ

BioEssays : news and reviews in molecular, cellular and developmental biology
1521-1878:e1700239 (2018)

PMID: 29574793

Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.

Freire-Pritchett P, Schoenfelder S, Várnai C

eLife
6 2050-084X: (2017)

PMID: 28332981

Derivation and Culture of Epiblast Stem Cell (EpiSC) Lines.

Rugg-Gunn P

Cold Spring Harbor protocols
2017 1559-6095:pdb.prot093971 (2017)

PMID: 28049783