Life Sciences Research for Lifelong Health
Kelsey Group members

Gavin Kelsey

Gavin obtained a B.Sc. in Biochemistry from King’s College London and then a Ph.D. in Genetics from University College London. Between 1987 and 1995 he was a post-doc at the German Cancer Research Center in Heidelberg, where he held a long-term post-doctoral fellowship from EMBO (1987-1999). In 1995 Gavin joined the Babraham Institute as a Group Leader, holding an MRC senior (non-clinical) fellowship from 1995-2005. He came to Babraham to identify and characterise new imprinted genes.

In addition to discovery of a number of imprinted genes, Gavin investigated imprinted gene effects on growth, metabolism and behaviour, and in human disease. His group currently focuses on understanding how epigenetic states are established in mammalian germ cells and early embryos, and the effects of ageing and diet on the integrity of epigenetic information and its transmission to the next generation.

In addition to his role as a Group Leader at Babraham, Gavin is affiliated to the University of Cambridge Centre for Trophoblast Research (, and is currently an Associate Editor of Clinical Epigenetics and a Faculty 1000 Member for Epigenetics & Epigenomics.

01223 496332

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Latest Publications

A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice.

Sendžikaitė G, Hanna CW, Stewart-Morgan KR

Nature communications
10 2041-1723:1884 (2019)

PMID: 31015495

Genomic Imprinting and Physiological Processes in Mammals.

Tucci V, Isles AR, Kelsey G

176 1097-4172:952-965 (2019)

PMID: 30794780

Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.

Rulands S, Lee HJ, Clark SJ

Cell systems
2405-4712: (2018)

PMID: 30031774

Epigenetic regulation in development: is the mouse a good model for the human?

Hanna CW, Demond H, Kelsey G

Human reproduction update
1460-2369: (2018)

PMID: 29992283

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.

Clark SJ, Argelaguet R, Kapourani CA

Nature communications
9 2041-1723:781 (2018)

PMID: 29472610

MLL2 conveys transcription-independent H3K4 trimethylation in oocytes.

Hanna CW, Taudt A, Huang J

Nature structural & molecular biology
25 1545-9985:73-82 (2018)

PMID: 29323282

Cultured bovine embryo biopsy conserves methylation marks from original embryo.

Fonseca Balvís N, Garcia-Martinez S, Pérez-Cerezales S

Biology of reproduction
97 1529-7268:189-196 (2017)

PMID: 29044423

Single-cell epigenomics: Recording the past and predicting the future.

Kelsey G, Stegle O, Reik W

Science (New York, N.Y.)
358 1095-9203:69-75 (2017)

PMID: 28983045

DNA Methylation in Embryo Development: Epigenetic Impact of ART (Assisted Reproductive Technologies).

Canovas S, Ros.s PJ, Kelsey G

BioEssays : news and reviews in molecular, cellular and developmental biology
1521-1878: (2017)

PMID: 28940661

Genomic imprinting beyond DNA methylation: a role for maternal histones.

Hanna CW, Kelsey G

Genome biology
18 1474-760X:177 (2017)

PMID: 28927436

The histone 3 lysine 4 methyltransferase Setd1b is a maternal effect gene required for the oogenic gene expression program.

Brici D, Zhang Q, Reinhardt S

Development (Cambridge, England)
1477-9129: (2017)

PMID: 28619824

Transcription and chromatin determinants of de novo DNA methylation timing in oocytes.

Gahurova L, Tomizawa SI, Smallwood SA

Epigenetics & chromatin
10 1756-8935:25 (2017)

PMID: 28507606