Krishnendu ChakrabortyKrish was awarded Ph.D. in Life Sciences from Jadavpur University, Kolkata, India in 2010. During his doctoral research he studied cancer mediated Immunosuppression and role of Neem leaf glycoprotein (NLGP) and Interferon alpha 2b as an immune modulator in the maintenance of immune homeostasis during head and neck squamous cell carcinoma (HNSCC). After finishing his doctoral thesis I joined Dept. of Pathobiological Sciences, Louisiana State University, USA and pursued his further research in the field of viral immunology. As a postdoctoral researcher he studied the role of immune modulatory cytokines in human metapneumo virus (hMPV) infection model. Presently he is working as a postdoctoral scientist in the Dept. of Lymphocyte Signalling Lab and Development, Babraham Institute, Cambridge, UK. His current interest is to determine the role of Phosphokinases and RNA binding proteins in Influenza virus infection.
Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of PIK3CD-encoded phosphoinositide 3-kinase δ.
Swan DJ, Aschenbrenner D, Lamb CA
Paz K, Flynn R, Du J
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function.
Chellappa S, Kushekhar K, Munthe LA
Journal of immunology (Baltimore, Md. : 1950)
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.
Stark AK, Chandra A, Chakraborty K
9 2041-1723:3174 (2018)
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
Gyori D, Lim EL, Grant FM
3 2379-3708: (2018)
Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.
Lim EL, Cugliandolo FM, Rosner DR
3 2379-3708: (2018)
Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes.
Benson RA, Garcon F, Recino A
Frontiers in immunology
9 1664-3224:1006 (2018)
Abdelrasoul H, Werner M, Setz CS
8 2045-2322:1327 (2018)
Kishore M, Cheung KCP, Fu H
47 1097-4180:875-889.e10 (2017)
Stubbs TM, Bonder MJ, Stark AK
18 1474-760X:68 (2017)
Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4(+) T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.
Mauro C, Smith J, Cucchi D
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy.
Okkenhaug K, Graupera M, Vanhaesebroeck B