Rafeah AlamRafeah graduated from University College London in 2010 with a BSc in Pharmacology. This was followed by a Master’s in Drug Discovery Skills at Kings College London in 2011. As part of her MSc she spent 5 months at AstraZeneca where she worked on assessing the impact of acute cytotoxic treatment on signalling pathways in human tumour models. Following her MSc degree, she spent 2 years working at UCB as a Research Assistant exploring the in vivo potential of some of the therapeutics focused on autoimmune diseases. Her current project as a PhD student at the Babraham Institute involves investigating the effect of overactive p110δ activity on T cell function in a model of a newly discovered primary immunodeficiency ‘’Activated PI3Kδ syndrome’’.
Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of PIK3CD-encoded phosphoinositide 3-kinase δ.
Swan DJ, Aschenbrenner D, Lamb CA
Paz K, Flynn R, Du J
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function.
Chellappa S, Kushekhar K, Munthe LA
Journal of immunology (Baltimore, Md. : 1950)
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.
Stark AK, Chandra A, Chakraborty K
9 2041-1723:3174 (2018)
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
Gyori D, Lim EL, Grant FM
3 2379-3708: (2018)
Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.
Lim EL, Cugliandolo FM, Rosner DR
3 2379-3708: (2018)
Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes.
Benson RA, Garcon F, Recino A
Frontiers in immunology
9 1664-3224:1006 (2018)
Abdelrasoul H, Werner M, Setz CS
8 2045-2322:1327 (2018)
Kishore M, Cheung KCP, Fu H
47 1097-4180:875-889.e10 (2017)
Stubbs TM, Bonder MJ, Stark AK
18 1474-760X:68 (2017)
Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4(+) T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.
Mauro C, Smith J, Cucchi D
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy.
Okkenhaug K, Graupera M, Vanhaesebroeck B