Molecular control of conventional and innate-like T cell development and function
My long-term research interest is to characterize molecular mechanisms that regulate the development and function of T cells. Together with my laboratory I made important contributions to the transcriptional control of Cd8 gene expression and identified that the transcription factor MAZR is an important regulator of CD8 expression as well as of CD4/CD8 lineage development. Moreover, I am interested in elucidating the roles of histone deacetylases (HDACs) in T cells and e.g. we recently identified that CD4+ T cell lineage integrity is regulated by HDAC1 and HDAC2. I have also a long-standing interest in revealing the role of Tec family kinases in the regulation of immune responses. In ongoing studies my team addresses topics like: (1) Transcriptional control of CD4/CD8 cell fate choice; (2) Transcription factor networks regulating peripheral T cell function; (3) Maintenance of T cell lineage identity, integrity and function; (4) Characterization of signaling pathways modulating Th differentiation.
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.
Dr Marc Veldhoen
The Brian Heap Seminar Room