‘MicroRNAs: micromanaging the pancreatic beta cell’

‘MicroRNAs: micromanaging the pancreatic beta cell’

Dr Matthew Poy, Max Delbrueck Center for Molecular Medicine In his writings on the milieu intérieur, Claude Bernard first hypothesized on the presence of feedback mechanisms within the cell to maintain its steady state physiology. Walter Bradford Cannon would subsequently build on this concept and coin the term homeostasis. To date, numerous counter-regulatory mechanisms have been characterized in the cell illustrating the dynamic nature of the intracellular environment. Among the more recently discovered is the microRNA (miRNA) pathway and currently, 2578 mature human miRNAs have been annotated in the miRBase database V20 which now catalogs 206 different plant and animal species. Importantly, since their identification in C.elegans, a canonical pathway has now been identified to describe how miRNAs are processed and incorporated into Argonaute-containing complexes to exert their effect on gene expression. Many insights into the functional role of miRNAs have been recently made, thereby improving our understanding of how these small RNAs integrate into the already complex landscape of regulating gene expression. Most notably, based on a number of miRNA knockout mouse models showing subtle phenotypes under steady state conditions, a hypothesis has steadily emerged suggesting the miRNA pathway contributes to cellular stress responses. Moreover, these observations are further supported by our recent study (Tattikota et al. 2014 Cell Metabolism) focusing on the role of Argonaute2 (Ago2) in the compensatory proliferation of the pancreatic b-cell during insulin resistance. These recent findings culminate over 10 years since our initial study which identified miR-375, a miRNA now established among the highest expressed sequences in this cell type. If you wish to meet with Dr Poy – please contact Ferdinand von Meyenn.

Event Time & Dates


Event Details

Ferdinand von Meyenn
Brian Heap Room