Babraham Lecture - Endoplasmic reticulum turnover via selective autophagy
The endoplasmic reticulum (ER) is the largest intracellular endomembrane system enabling synthesis and transport of cellular components. Constant ER turnover is needed to meet different cellular requirements and autophagy plays an important role in this process. In mammalian cells the ER is degraded via a selective autophagy pathway (called ER-phagy), mediated by specific ER-resident proteins that interacts with LC3, via conserved LC3-interacting region (LIR). Reticulon-type protein FAM134B is responsible for the turnover of ER sheets as its overexpression stimulates ER fragmentation and delivery to lysosomes via the autophagy pathway. Conversely, blockade of autophagy or depletion of FAM134B triggers a marked increase in the ER volume. Mutations of FAM134B in humans are unable to act as ER-phagy receptors and cause sensory neurodegeneration. We have recently identified full length reticulon 3 (RTN3) as a specific receptor for the degradation of ER tubules. The major questions we are exploring at the moment deal with the action of reticulone domains in banding the membranes and the regulatory mechanisms of a family of co-receptors that assist FAM134B or RTN3 proteins in selecting the appropriate cargoes during the ER-phagy process. Taken together, ER-phagy possesses the potential to remodel or rebalance the entire ER network and – given the physical and functional connection of ER to other organelles inside the cell – ER-phagy might also impact the function of other organelles as well.
A catered networking session will follow this lecture.
If you are external to the Campus and would like to attend this lecture, please contact us to arrange site access - firstname.lastname@example.org
|Starts||02:00 pm - 21/11/2018|
|Ends||03:00 pm - 21/11/2018|
|Contact||Dr Nick Ktistakis|
|Location||The Cambridge Building - Petersfield Lecture Theatre|
|Speaker||Prof. Ivan Dikic|
|Speaker Affiliation||Director of the Institute of Biochemistry II (IBC2), Goethe University, Frankfurt, Germany|
7 November, 2018