Cellular responses to DNA damage: from mechanistic insights to applications in cancer therapyAs DNA is frequently subject to a wide array of molecularly distinct forms of damage, life has evolved multiple DNA repair and associated processes, collectively termed the DNA-damage response (DDR). The importance of DDR mechanisms is underlined by their deregulation or loss causing cancer and various human genetic disorders whose pathologies include stem-cell exhaustion, developmental defects, infertility, immune-deficiency, neuro-degeneration, cancer predisposition and/or premature ageing. Work in my laboratory aims to decipher DDR mechanisms, particularly those triggered by DNA double-strand breaks. In this talk, I will describe some of our recent work using CRISPR-Cas9 genetic screens and ensuing mechanistic studies to identify new DDR factors/regulators and then define their functions. I will also explain how such work is identifying new avenues for anti-cancer therapy and is helping us understand how cancer cells can evolve resistance to therapeutic agents.
A catered networking session will follow this lecture.
If you would like to attend this lecture, please contact us to arrange site access - email@example.com
|Starts||02:00 pm - 11/09/2018|
|Ends||03:00 pm - 11/09/2018|
|Contact||Dr Jon Houseley|
|Location||The Cambridge Building - Petersfield Lecture Theatre|
|Speaker||Prof. Steven Jackson|
|Speaker Affiliation||Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge|
9 August, 2018