Life Sciences Research for Lifelong Health

Interrogating T cell signalling and effector function in hypoxic environments

Effector CD8+ Cytotoxic T lymphocytes (CTL) play a vital role in eliminating infected and diseased cells. Defining the signalling networks and molecular mechanisms that govern CD8+ T cell differentiation and optimal effector function is key to understanding T cell pathologies and discovering new molecular targets and strategies for therapies. During an immune response, T cell behavior can be shaped by microenvironmental cues. Critically, CTL are confronted by low oxygen in both physiological and pathological immunological niches. I have been using biochemistry, single-cell approaches and quantitative mass spectrometry methodologies in order to dissect signalling pathways and identify molecules that control T cell differentiation and effector function. My research goal is to develop an understanding of how environmental oxygen levels regulate the function of effector CTL with the aim of developing a framework that will allow improved understanding of how hypoxia can shape T cell responses. This talk will discuss novel insights into signalling mechanisms and transcriptional regulators that link oxygen sensing to the control of CD8+ T cell differentiation and function.

If you would like to attend this seminar, please contact us to arrange site access - seminars@babraham.ac.uk

Event Time & Dates

Starts01:00 pm - 05/02/2018
Ends02:00 pm - 05/02/2018

Event Details

Contact Dr Martin Turner
LocationKings Hedges Room - The Cambridge Building
SpeakerDr Sarah Ross
Speaker AffiliationUniversity of Dundee, Scotland

Posted

16 January, 2018