Life Sciences Research for Lifelong Health

Regulatory feedback from nascent RNA to chromatin

Transcription and chromatin function are regulated by proteins that bind DNA, nucleosomes or RNA polymerase II, with specific non-coding RNAs (ncRNAs) functioning to modulate their recruitment or activity. By contrast, nascent pre-mRNA has primarily been considered a passive player in these processes. Focusing on polycomb repressive complex 2 (PRC2), I will present data from our lab that suggest that nascent pre-mRNA in fact plays an active role in regulating chromatin state. I will also discuss recent work revealing the transcriptional mechanisms underlying lineage specification of CD4+ T cells and how disregulation of these mechanisms is associated with increased risk of auto-inflammatory disease.

If you would like to attend this seminar, please contact us to arrange site access -

Event Time & Dates

Starts01:00 pm - 15/03/2017
Ends02:00 pm - 15/03/2017

Event Details

Contact Dr Martin Turner
LocationThe Brian Heap Seminar Room
SpeakerDr Richard Jenner
Speaker AffiliationUCL Cancer Institute, University College London
Speaker Link


9 February, 2017