Life Sciences Research for Lifelong Health

Regulation of X-chromosome inactivation in human Development

Sex-chromosome dosage compensation is essential in most metazoan, yet the developmental timing and the underlying strategies are remarkably variable, even amongst placental mammals. In the latter, dosage compensation is achieved through the inactivation of one X chromosome in females, a process that has been so far mostly studied in the mouse, where actors and mechanisms have been characterized. Here we will discuss new insights into how the activity of the X chromosome is regulated in human early development, and how long noncoding RNAs are contributing to this process.

If you would like to attend this seminar, please contact us to arrange site access -


Event Time & Dates

Starts01:00 pm - 28/02/2017
Ends02:00 pm - 28/02/2017

Event Details

Contact Dr Peter Rugg-Gunn
LocationThe Brian Heap Seminar Room
SpeakerDr Claire Rougeulle
Speaker AffiliationThe National Center for Scientific Research (CNRS), Paris, France


2 February, 2017