Life Sciences Research for Lifelong Health

The context dependence of Ras biology

Ras GTPases are important hubs in a key cellular communication pathway that regulates the rate at which cells divide and proliferate. Mutations of components of this pathway are found in the almost all cancers and specific mutations of Ras are present in 30% of human cancer cases. Cells express three closely related isoforms of Ras called HRAS, KRAS and NRAS. Despite their similarity they have different biological functions and one isoform: KRAS is the most frequently mutated in human cancers. My lab is characterizing the differences between these isoforms and investigating the mechanisms responsible for isoform-specific signalling. Intriguingly, we also find that different activating mutations specify different endogenous KRAS outputs.

If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.

Event Time & Dates

Starts01:00 pm - 17/11/2016
Ends02:00 pm - 17/11/2016

Event Details

Contact Dr Simon Cook
LocationThe Brian Heap Seminar Room
SpeakerProf. Ian Prior
Speaker AffiliationInstitute of Translational Medicine, University of Liverpool
Speaker Link


1 November, 2016