Life Sciences Research for Lifelong Health

The pros and cons of CD8 T cells in respiratory infections

CD8 T cells are vital for clearing acute infections; because of this they make an attractive target for vaccine development. Using a number of different vaccine platforms we have been investigating the role of CD8 T cells in protection against Respiratory Syncytial Virus (RSV) and Influenza. We have shown a protective role for DNA vaccine induced CD8 T cells in influenza. The situation for RSV is more complex with timing, route and formulation all affecting the type of CD8 T cells induced. Immunisation with a DNA vaccine leads to a large influx of CD8 T cells into the lung, but they are associated with disease not protection; likewise RSV infection in early leads to the generation of pathogenic CD8 T cells. However, RSV infection as an adult induces a population of resident memory CD8 T cells in the lung that are protective not disease enhancing. We are now investigating vaccine strategies to induce these protective T cells.

If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.

Event Time & Dates

Starts11:00 am - 08/06/2016
Ends12:00 pm - 08/06/2016

Event Details

Contact Dr Martin Turner
LocationThe Brian Heap Seminar Room
SpeakerDr John Tregoning
Speaker AffiliationSenior lecturer in Mucosal Infection and Immunity, Section of Virology, Imperial College London
Speaker Link


24 May, 2016