Life Sciences Research for Lifelong Health

CD4 T cell help for humoral immunity in transplantation

In clinical transplantation the development of class-switched humoral immunity directed against either donor alloantigen or autoantigen is increasingly associated with early allograft failure. MHC alloantigen is a classical T-dependent antigen, and our work has focused on how CD4 T cell help is provided for generating destructive antibody responses directed against transplant antigen. In this seminar, I will provide an overview of our recent studies of murine transplant models, which have revealed novel aspects of the cognate interaction between CD4 T cells and B cells. Our findings suggest that the concept of ‘linked’ help is not as robust as previously proposed, that different helper T cell populations may be responsible for maintaining germinal centre responses than for their initiation, and that ‘peptide-degenerate’ recognition of MHC class II complexes on the B cell surface triggers global activation of all B cells. I’m therefore hopeful that our findings will be of interest to non-transplant B cell immunologists and generate productive discussion.
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.

Event Time & Dates

Starts04:00 pm - 22/02/2016
Ends05:00 pm - 22/02/2016

Event Details

Contact Dr Martin Turner
LocationThe Brian Heap Seminar Room
SpeakerDr Gavin Pettigrew
Speaker AffiliationDepartment of Surgery, School of Clinical Medicine, University of Cambridge
Speaker Link


11 January, 2016