Life Sciences Research for Lifelong Health

NF-κB: a master regulator of the cellular response to stress and infection

NF-kB subunits are effectors for an incredibly diverse range of cell stimuli and stresses. Although best known for their roles in the inflammatory and immune responses NF-kB subunits also respond environmental challenges such as DNA damage, oxidative stress and hypoxia. The consequences of NF-kB activation do not fall into a 'one size fits all' category. Different genes become activated or repressed depending on a variety of contextual modulators, including the activity of parallel signalling pathways and transcription factors. My lab has been interested in the pathways that control the differential responses of NF-kB to inflammatory and DNA damage stimuli. In particular we have previously characterised how crosstalk with the p53 tumour suppressor can affect NF-kB function in cancer and how NF-kB can mediate pro-apoptotic responses following DNA replication stress (in contrast to its anti-apoptotic functions following stimulation with inflammatory cytokines). Recently we have been investigating how the NF-kB response to DNA replication stress affects its roles in mouse models of B-cell lymphoma, liver regeneration and hepatocellular carcinoma.
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.

Event Time & Dates

Starts01:00 pm - 16/02/2016
Ends02:00 pm - 16/02/2016

Event Details

Contact Dr Simon Cook
LocationThe Brian Heap Seminar Room
SpeakerProf Neil Perkins
Speaker AffiliationInstitute for Cell and Molecular Biosciences (ICaMB), Newcastle University
Speaker Link


12 November, 2015