Life Sciences Research for Lifelong Health



Finalised Programme for ‘PI3-Kinases in Immunity, Inflammation and Infection’

The Babraham Institute is hosting a one day meeting on Monday 23rd June 2014 from 10am – 6pm on ‘PI3-Kinases in Immunity, Inflammation and Infection’.  The event is open to all research scientists, PhD students, postdocs and PIs with an interest in PI3-kinase research. A plenary lecture will be given by Dr Roger Williams from the MRC-Laboratory of Molecular Biology on ‘The Structure and Function of PI3-Kinase Isoforms.  This lecture will be followed by a series of short talks, poster session and BBQ.

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09:15 – 10:00      Registration
10:00 – 10:30      Roger Williams, MRC-LMB The structure and function of PI3-Kinase isoforms  
10:30 – 10:45      Alison Condliffe, University of Cambridge                                    
Activated PI3-Kinase delta syndrome, a newly described immune deficiency syndrome
10:45 – 11:00      Nital Sumaria, Blizard Institute, QMUL
A requirement for PI3-Kinase in gamma delta T cell development  
11:00 – 11:15      Jean-Marc Doisne, University of Cambridge                                    
Immunomodulation of selective naïve T cell functions by p110. Inactivation improves the outcome of allogeneic hematopoietic cell transplantation
11:15 – 11:30      Amy MacQueen, Babraham Institute                                    
Differential roles for the Class IA PI3-Kinases p110α and p110δ in T cell activation
11:30 – 12:00      Coffee
12:00 – 12:15      David Finlay, Trinity College Dublin                                    
mTORC1-dependent metabolic reprogramming is a prerequisite for pro-inflammatory natural killer cell functions
12:15 – 12:30      Esther Castellano-Sanchez, Bart’s Cancer Institute QMUL                                  
Understanding the role of Ras-PI3-Kinase signalling in lung cancer tumour associated macrophage recruitment
12:30 – 12:45      Priyanka Tibarewal, Heriot-Watt University Edinburgh                                    
Dissection of PTEN mediated tumour suppression in whole-body and T cell specific transgenic mice
12:45 – 13:00      Yohei Ohashi, MRC-LMB Characterisation of a new subunit of the Class III PI3-Kinase complex 1  
13:00 – 14:00      Lunch 14:00 – 14:15      Mark Coles, University of York                                  
Essential role for PI3-Kinase dependent chemotaxis in neutrophil dynamics in tissue draining lymph nodes
14:15 – 14:30      Georgia Walton, University of Birmingham                                    
Abnormal neutrophil migration is a feature of early COPD and causally related to increased PI3-Kinase signalling
14:30 – 14:45      Arnaud Deladeriere, Babraham Institute
PI3-Kinase gamma regulatory subunits control different neutrophil functions  
14:45 – 15:00      Malcolm Begg, GSK                                    
The effect of a novel PI3-Kinase delta inhibitor on PIP3 levels in sputum from the lungs of healthy smokers
15:00 – 15:15      Coffee 15:15 – 15:30      Tom Blair, University of Bristol                                    
Redundant roles of PI3-Kinase isoforms p110α and p110β in primer-mediated platelet potentiation
15:30 -15:45        Ezra Aksoy, William Harvey Research Institute, QMUL                                    
The isoform selective role of PI3-Kinases in crystal uptake and inflammasome-mediated disease
15:45 – 16:00      Jennifer Ball, University of Bath                                    
Effect of pharmacological targeting of SHIP on activation, adhesion and migration of human T lymphocytes
16:00 – 16:15      Chris Rudd, University of Cambridge PI3-Kinase in T-cells; a role in CD28 priming of antigen receptor responses  
16:15 – 17:30      Poster Session and Drinks
17:30                     BBQ


1 June, 2014