Life Sciences Research for Lifelong Health
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The latest version of the programme can be downloaded here (times and order are subject to change).  

Please note, the closing date for the conference is the 3rd March 2017.  Places are filling up fast, so book your place now to avoid disappointment.  



Monday 27 March 2017

08:30 Registration
08:50 Opening Remarks
Prof. Michael Wakelam, Babraham Institute
09:00 Plenary; New discoveries about ageing in C.elegans
Prof. David Gems, Institute of Healthy Ageing, University College London


Session 1: The Ageing Stem Cell

Chair: Dr. Elisa Laurenti, Wellcome Trust - MRC Cambridge Stem Cell Institute
09:45 Epigenetic stress response and stem cell aging
Dr. Karl Lenhard Rudolph, Leibniz Institute on Aging (FLI)
10:15 DNA methyltransferase 3A in hematopoiesis
Prof. Margaret (Peggy) Goodell, Baylor College of Medicine
10:45 Coffee Break
11:15 Novel epigenetic biomarker and its clinical utility in diagnostics of Alzheimer's disease
Dr. Victoria V. Lunyak, Aelan Cell Technologies
11:45 Autophagy and metabolism of aged hematopoietic stem cells
Dr. Emmanuelle Passegué, UCSF School of Medicine
12:15 Singe cell sequencing reveals age-dependent emergence of pre-malignant haematopoietic stem cells
Dr. Kristina Kirschner, Institute of Cancer Sciences, University of Glasgow - Selected Talk
12:30 Impaired immunoglobin repertoire and epigenetic alterations in ageing B cell development
Dr. Anne Corcoran, Babraham Institute
13:00 Lunch

Session 2: The Ageing Immune System

Chair: Prof. Janet Lord, Institute of Inflammation and Ageing, University of Birmingham
14:15 The epigenetic landscape of CD8 T cells in differentiation and ageing
Prof. Jörg J. Goronzy, Stanford School of Medicine
14:45 A global MAPK activation complex coordinated by Sestrins inhibits immunity during ageing
Prof. Arne Akbar, Windeyer Institute, University College London
15:15 Ageing and the germinal centre response
Dr. Michelle Linterman, Babraham Institute
15:45 Afternoon Tea
16:15 Age-Related Functional Defects in Naïve CD8 T Cells Due to Defective TCR Signaling and Inhibition of Cell Cycle
Dr. Kylie Quinn, Monash University - Selected Talk
16:30 Ageing, inflammation and poor B cell response
Dr. Bonnie Blomberg, University of Miami Miller School of Medicine
17:00 Developing mTOR inhibitors for the treatment of ageing-related conditions in humans
Dr. Joan Mannick, Novartis
17:15 Poster Session
19:30 Conference Dinner


Tuesday 28 March 2017


Session 3: Signalling and the Ageing Cell

Chair: Prof. Michael Wakelam, Babraham Institute
09:00 Plenary; Nutrition and ageing
Prof. Dame Linda Partridge, Institute of Healthy Ageing, University College London
09:45 Robust and reproducible chemical interventions in ageing
Prof. Gordon Lithgow, Buck Institute for Research on Ageing
10:15 The SKN-1 transcription factor can protect against oxidative damage and increase lifespan in C. elegans by distinct mechanisms
Dr. Jennifer Tullet, School of Biosciences, University of Kent - Selected Talk
10:30 Coffee Break
11:00 Signalling pathways during cell senescence and upon senescence reversal by mTOR inhibition revealed by proteomics analysis
Prof. Lynne Cox, University of Oxford - Selected Talk
11:15 Correcting signaling dysregulation in neutrophils and improving immunity in older adults
Prof. Janet Lord, Institute of Inflammation and Ageing, University of Birmingham
11:45 Dynamics of autophagy starting from mTOR
Dr. Nick Ktistakis, Babraham Institute
12:15 Lunch


Session 4: Epigenetics of the Ageing Cell

Chair: Dr Olivia Casanueva and Dr Len Stephens, Babraham Institute
13:30 Genetic studies of the epigenetic clock
Prof. Steve Horvath, University of California, Los Angeles
14:00 Convergent mechanisms of longevity
Prof. Adam Antebi, Max Planck Institute for Biology of Ageing
14:30 Plenary; Regulation of Growth by the mTOR Pathway
Prof. David Sabatini, Whitehead Institute, Massachusetts Institute of Technology
15:15 Afternoon Tea
15:45 Mouse epigenetic age and prediction
Mr. Thomas Stubbs, Babraham Institute - Selected Talk
16:00 It’s not all down to the egg: Maternal age impacts on key developmental pathways in pregnancy
Dr Myriam Hemberger, Babraham Institute
16:15 Linking senescence and inflammation: the senescence-associated secretory phenotype (SASP)
Prof. Jesús Gil, Imperial College London
16:45 Closing remarks
17:00 Depart


Organising Committee

Michael Wakelam Institute Director
Simon Cook Signalling Group Leader
Michelle Linterman Lymphocyte Signalling and Development Group Leader
Patrick Varga-Weisz Nuclear Dynamics Group Leader
Peter Rugg-Gunn Epigenetics Group Leader
Linden Fradet Knowledge Exchange Manager
Tacita Nye Public Engagement Manager