Next Generation Sequencing FacilityWhilst the Human Genome Project sequenced the first complete human genome over the course of fifteen years and a cost of more than 2 billion US dollars, the advent of Next Generation Sequencing – an approach to sequencing nucleic acids that generates gigabases of genetic data on a single instrument run - has made it possible to sequence a large genome in a matter of days, for several thousand dollars. Furthermore, Next Generation Sequencing technology has revolutionised post-genomics studies of gene expression, genetic regulation and nuclear dynamics.
The flexibility of Next Generation Sequencing technology allows almost any genetic material to be studied on a genome-wide scale. This technology has therefore become a key tool in the study of microRNAs, transcription and gene expression, epigenetic DNA modifications and chromosomal configuration. The Babraham Institute has established a Next Generation Sequencing Facility, with investment from the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC), in partnership with the University of Cambridge’s Centre for Trophoblast Research. The Facility will play a crucial role in the Institute’s research projects on epigenetics, chromatin regulation, cell signalling and immunology, and is also available to external users on a fee-for-service basis.