Life Sciences Research for Lifelong Health

Lipids we can analyse

Neutral lipids
  1. Fatty acid (FA)
  2. Fatty acyl CoA (FaCoA, intermediate in fatty acids synthesis)
  3. Fatty acyl carnitine (FaCN, shutter of fatty acids β-oxidation)
  4. Monoacylglycerol (MG)
  5. Diacylglycerol (DG)
  6. Triacylglycerol (TG)
  7. Cholesterol (CH)
  8. Cholesterol ester (CE)
  9. The corresponding ether lipids

Phospholipids
  1. Phosphatidic acid (PA)
  2. Phosphatidylethanol (PEtOH) (or phosphatidylbutanol, PBuOH)
  3. Phosphatidylglycerol (PG)
  4. Phosphatidylcholine (PC)
  5. Platelet-activating factor (PAF)
  6. Phosphatidylethanolamine (PE)
  7. Phosphatidylinositol (PI)
  8. Monophosphorylated phosphatidylinositol (PIP)
  9. Bisphosphorylated phosphatidylinositol (PIP2)
  10. Trisphosphorylated phosphatidylinositol (PIP3)
  11. Phosphatidylserine (PS)
  12. Cardiolipin (CL)
  13. The corresponding lyso-phospholipids (LPL)
  14. ‚ÄčThe corresponding ether lipids
Sphingolipids
  1. Sphingosine (SG)
  2. Sphingosine-1-phosphate (S1P)
  3. Ceramide (Cer)
  4. 2-hydroxylceramide (2-OH-Cer)
  5. Ceramide-1-phosphate (Cer1P)
  6. Sphingomyelin (SM)
  7. Sphingosine-1-phosphorylcholine (SPC)
  8. Mono-Sulfo Galactosyl Ceramide (Sul-Gal-Cer)
  9. The corresponding dihydro-sphingolipids

Taken into consideration the importance of both lipid metabolism and signalling pathways, we are establishing methods to analyse:
  1. Eicosanoids including prostaglandins and leukotrienes etc
  2. Steroid hormones
  3. Free and conjugated bile acids
  4. Fat-soluble and water-soluble vitamins
We also aim to establish methodologies to analyse any lipid proposed by collaborators (internal and external of BI) and additionally any chemicals of appropriate biological significance.

‚ÄčThe facility will also work with collaborators upon the purification of endogenous signalling molecules.