Life Sciences Research for Lifelong Health

Group Members

Dr Jonathan Clark

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Dr Izabella Niewczas

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Latest Publications

Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations.

Huang-Doran I, Tomlinson P, Payne F

JCI insight
1 :e88766 (2016)

PMID: 27766312

Dynamics of mTORC1 activation in response to amino acids.

Manifava M, Smith M, Rotondo S

eLife
5 2050-084X: (2016)

PMID: 27725083

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.

Lochhead PA, Clark J, Wang LZ

Cell cycle (Georgetown, Tex.)
15 1551-4005:506-18 (2016)

PMID: 26959608

The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles.

Frej AD, Clark J, Roy CL

Molecular and cellular biology
1098-5549: (2016)

PMID: 26951199

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, Abdelmohsen K, Abe A

Autophagy
12 1554-8635:1-222 (2016)

PMID: 26799652

Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells.

Anderson KE, Juvin V, Clark J

Advances in biological regulation
2212-4934: (2015)

PMID: 26639089

Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling.

Clark J,Kay RR,Kielkowska A,Niewczas I,Fets L,Oxley D,Stephens LR,Hawkins PT

The EMBO journal
1460-2075: (2014)

PMID: 25180230

A new approach to measuring phosphoinositides in cells by mass spectrometry.

Kielkowska A, Niewczas I, Anderson KE

Advances in biological regulation
54 2212-4934:131-41 (2014)

PMID: 24120934

Two distinct functions for PI3-kinases in macropinocytosis.

O Hoeller, P Bolourani, J Clark

Journal of cell science
126 Pt 18:4296-307 (2013)

DOI: 10.1242/jcs.134015

PMID: 23843627