Life Sciences Research for Lifelong Health

Hannah Johnson

Hannah entered into science due to a fascination with mass spectrometry techniques and how they can be used to gain quantitative insight into cellular signalling. During her PhD in Professor Simon Gaskell’s lab at the University of Manchester she developed methodologies for the absolute quantification of phosphorylation stoichiometry. From there, to put her love of mass spectrometry to the test, she worked as a post-doc in the lab of Forest White at MIT where she applied mass spectrometric methodologies to understand the effects of deregulated receptor tyrosine kinases on tyrosine phosphorylation signalling in human glioblastoma. Hannah hopes to further develop her skill set in the Cook lab by aiming to understand how cancer cells become resistant to small molecule inhibitors to receptor tyrosine kinases such as FGFR. Hannah’s outside interests include embroidery, reading, and movies.

Latest Publications

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.

Galloway A, Saveliev A, Łukasiak S

Science (New York, N.Y.)
352 1095-9203:453-9 (2016)

PMID: 27102483

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.

Lochhead PA, Clark J, Wang LZ

Cell cycle (Georgetown, Tex.)
15 1551-4005:506-18 (2016)

PMID: 26959608

Maternal DNA Methylation Regulates Early Trophoblast Development.

Branco MR, King M, Perez-Garcia V

Developmental cell
36 1878-1551:152-63 (2016)

PMID: 26812015

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.

Caunt CJ, Sale MJ, Smith PD

Nature reviews. Cancer
15 1474-1768:577-92 (2015)

PMID: 26399658

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.

Ashford AL, Dunkley TP, Cockerill M

Cellular and molecular life sciences : CMLS
1420-9071: (2015)

PMID: 26346493

Intrinsic and acquired resistance to MEK1/2 inhibitors in cancer.

Sale MJ, Cook SJ

Biochemical Society transactions
42 1470-8752:776-83 (2014)

PMID: 25109957