Life Sciences Research for Lifelong Health
Wakelam Group

Simon Rudge

Simon studied for his BSc Hons in Biochemistry at the University of Bristol. After completing his PhD in Biochemistry at the University of Birmingham, he took up post-doctoral positions in the USA. During this time, Simon started working on phospholipase D-mediated signalling in the yeast Sacchromyces cerevisae, and this work resulted in the cloning and characterisation of PLD1 and PLD2. Simon returned to the UK to join Professor Wakelam’s laboratory and continue his research on PLD enzymes. Simon regularly mentors visiting summer students in the lab, and has recently participated in the Institute’s collaboration with the newly opened University Technical College Cambridge. He enjoys being an active member of the Athena Swan and public engagement committees.

Latest Publications

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.

Farquhar MJ, Humphreys IS, Rudge SA

Journal of hepatology
1600-0641: (2017)

PMID: 28126468

Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis.

Kilbey A, Terry A, Wotton S

Journal of cellular biochemistry
118 1097-4644:1432-1441 (2017)

PMID: 27869314

Using lipidomics analysis to determine signalling and metabolic changes in cells.

Nguyen A, Rudge SA, Zhang Q

Current opinion in biotechnology
43 1879-0429:96-103 (2017)

PMID: 27816901

Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations.

Huang-Doran I, Tomlinson P, Payne F

JCI insight
1 :e88766 (2016)

PMID: 27766312

The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.

Vermeren MM, Zhang Q, Smethurst E

PloS one
11 1932-6203:e0162814 (0)

PMID: 27658289

C13orf31 (FAMIN) is a central regulator of immunometabolic function.

Cader MZ, Boroviak K, Zhang Q

Nature immunology
1529-2916: (2016)

PMID: 27478939

Purification, characterization and crystallization of the F-ATPase from Paracoccus denitrificans.

Morales-Rios E, Watt IN, Zhang Q

Open biology
5 2046-2441: (2015)

PMID: 26423580