Matthew WhiteMatthew graduated with a degree in Biomedical Science at the University of Cardiff in 2009 before completing a PhD in Developmental Neuroscience with Alun Davies in 2014. Here he studied the role of TNF superfamily members in the growth and survival of peripheral sympathetic neurons using primary cultured cells and transgenic models. He now works for Jemeen Sreedharan within the Coleman group investigating the biology of ALS motor neuron disease through a combination of in vitro primary neuronal culture and molecular techniques. The work aims to identify and characterise novel suppressors of TDP-43 toxicity in motor neurons.
NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo.
Di Stefano M, Loreto A, Orsomando G
Current biology : CB
KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons.
Hung CO, Coleman MP
Traffic (Copenhagen, Denmark)
Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.
Harwell CS, Coleman MP
11 1750-1326:44 (2016)
Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies.
Clark DE, Waszkowycz B, Wong M
Bioorganic & medicinal chemistry letters
Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.
Gilley J, Ando K, Seereeram A
Neurobiology of aging
39 1558-1497:1-18 (2016)
Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.
Rodríguez-Martín T, Pooler AM, Lau DH
Neurobiology of disease
85 1095-953X:1-10 (2015)
Short-term diabetic hyperglycemia suppresses celiac ganglia neurotransmission, thereby impairing sympathetically mediated glucagon responses.
Mundinger TO, Cooper E, Coleman MP
American journal of physiology. Endocrinology and metabolism
309 1522-1555:E246-55 (2015)
Gilley J, Orsomando G, Nascimento-Ferreira I
10 2211-1247:1974-81 (2015)
Axonal transport declines with age in two distinct phases separated by a period of relative stability.
Milde S, Adalbert R, Elaman MH
Neurobiology of aging
The Axon-Protective WLD(S) Protein Partially Rescues Mitochondrial Respiration and Glycolysis After Axonal Injury.
Godzik K, Coleman MP
Journal of molecular neuroscience : MN
Di Stefano M, Nascimento-Ferreira I, Orsomando G
Cell death and differentiation
Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2).
Milde S, Coleman MP
The Journal of biological chemistry
289 1083-351X:32858-70 (2014)