Life Sciences Research for Lifelong Health

Research

Increasing evidence suggests that the three dimensional, spatial organisation of the genome in the interphase nucleus plays a fundamental role in regulating genome function. At the highest level, individual chromosomes are tissue-specifically arranged in interphase such that frequent juxtaposition of ‘preferred neighbour’ chromosomes occurs, suggesting a role in cell-type specific gene expression patterns.

Some of our past and present research areas:

Promoter Capture Hi-C

Cell-to-cell variability in chromosome structure

Preferential associations between co-regulated genes

Non-coding RNA and epigenetic silencing of gene expression

Long range chromatin interactions