Life Sciences Research for Lifelong Health

Patrick Varga-Weisz

Research Summary

​Chromatin is a highly dynamic structure to accommodate its many tasks in regulating, organizing, safeguarding and packaging the genetic material. We are interested in understanding the mechanisms behind this sophisticated cellular machinery.

HeterochromatinKey components that impart this dynamic state are special enzymes, so called chromatin remodelling factors, many of which target the nucleosome, the basic building block of chromatin.

The enzymology of chromatin remodelling is a largely new territory with opportunities for many exciting discoveries. One particular class of chromatin remodelling factors uses the energy gained by ATP hydrolysis to remodel nucleosomes: The nucleosome may be shifted, altered or blasted away, but some of these factors, such as Imitation Switch (ISWI), are also involved in nucleosome assembly.

The Varga-Weisz laboratory studies such ATP-dependent nucleosome remodelling factors, their role in the cell (in chromatin replication) and their mechanisms of action.

Latest Publication:
ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior
Nature Medicine Advance Online Publication 21 Sep 2015
http://dx.doi.org/10.1038/nm.3939
 

Group Members

Latest Publications

ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior.

Sun H, Damez-Werno DM, Scobie KN

Nature medicine
1546-170X: (2015)

PMID: 26390241

A novel phosphate-starvation response in fission yeast requires the endocytic function of Myosin I.

Petrini E, Baillet V, Cridge J

Journal of cell science
1477-9137: (2015)

PMID: 26345368

Chromatin remodeling: a collaborative effort.

Varga-Weisz PD

Nature structural & molecular biology
21 1545-9985:14-6 (2014)

PMID: 24389547

Keeping chromatin quiet: how nucleosome remodeling restores heterochromatin after replication.

JE Mermoud, SP Rowbotham, PD Varga-Weisz

Cell cycle (Georgetown, Tex.)
10 23:4017-25 (2011)

DOI: 10.4161/cc.10.23.18558

PMID: 22101266

Insights into how chromatin remodeling factors find their target in the nucleus.

PD Varga-Weisz

Proceedings of the National Academy of Sciences of the United States of America
107 46:19611-2 (2010)

DOI: 10.1073/pnas.1014956107

PMID: 21059914

The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci.

A Neves-Costa, WR Will, AT Vetter

PloS one
4 12:e8111 (2009)

DOI: 10.1371/journal.pone.0008111

PMID: 19956593

Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism.

CJ Hogan, S Aligianni, M Durand-Dubief

Molecular and cellular biology
30 3:657-74 (2010)

DOI: 10.1128/MCB.01117-09

PMID: 19933844

The regulation of ATP-dependent nucleosome remodelling factors.

C Hogan, P Varga-Weisz

Mutation research
618 1-2:41-51 (2007)

DOI: 10.1016/j.mrfmmm.2006.07.010

PMID: 17306842

Regulation of higher-order chromatin structures by nucleosome-remodelling factors.

PD Varga-Weisz, PB Becker

Current opinion in genetics & development
16 2:151-6 (2006)

DOI: 10.1016/j.gde.2006.02.006

PMID: 16503135