Life Sciences Research for Lifelong Health

Rabab Nasrallah

Rabab gained an Honours in Medical Sciences from the University of New South Wales in Australia before undertaking her PhD studying the transcriptional regulation of embryonic stem cell differentiation into the hematopoietic lineage under the joint supervision of John Pimanda at the University of New South Wales, and Georges Lacaud and Valerie Kouskoff at the CRUK Manchester Institute. Her work established a novel role for Endoglin in early haematopoietic development and the patterning of tissue-specific enhancer activation that drives appropriate induction of haematopoiesis. Rabab’s work in Rahul Roychoudhuri’s group aims to understand how extrinsic signals modulate transcription factor function within lymphocytes to dictate the outcome of immune responses.

Latest Publications

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Eil R, Vodnala SK, Clever D

537 1476-4687:539-543 (2016)

PMID: 27626381

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

Clever D, Roychoudhuri R, Constantinides MG

166 1097-4172:1117-1131.e14 (2016)

PMID: 27565342

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.

Roychoudhuri R, Clever D, Li P

Nature immunology
1529-2916: (2016)

PMID: 27158840

The transcription factor BACH2 promotes tumor immunosuppression.

Roychoudhuri R, Eil RL, Clever D

The Journal of clinical investigation
1558-8238: (2016)

PMID: 26731475

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

Sukumar M, Liu J, Mehta GU

Cell metabolism
1932-7420: (2015)

PMID: 26674251

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.

Klebanoff CA, Scott CD, Leonardi AJ

The Journal of clinical investigation
1558-8238: (2015)

PMID: 26657860

Oncogenic PI3Kα promotes multipotency in breast epithelial cells.

Okkenhaug K, Roychoudhuri R

Science signaling
8 1937-9145:pe3 (2015)

PMID: 26535006

Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape.

Crompton JG, Narayanan M, Cuddapah S

Cellular & molecular immunology
2042-0226: (2015)

PMID: 25914936

The interplay of effector and regulatory T cells in cancer.

Roychoudhuri R, Eil RL, Restifo NP

Current opinion in immunology
33C 1879-0372:101-111 (2015)

PMID: 25728990

Super-enhancers delineate disease-associated regulatory nodes in T cells.

Vahedi G, Kanno Y, Furumoto Y

1476-4687: (2015)

PMID: 25686607