Life Sciences Research for Lifelong Health

Firas Sadiyah

Firas gained an MSc in Biotechnology from Hanover Medical School (MHH) where he studied the molecular regulation of haematopoietic stem cell differentiation. Firas moved to the USA to continue this work as a research scholar at University of California in San Francisco (UCSF). At UCSF, Firas' research elucidated lineage-specific roles of key oncogenic proteins in acute lymphoblastic leukaemia (ALL) and chronic myeloid leukaemia (CML).

Firas is now in Rahul Roychoudhuri’s group at the Babraham Institute, investigating how long range enhancer-promoter interactions drive cell-fate decisions within the CD4+ T cell lineage to dictate the outcome of immune responses. 

Latest Publications

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Eil R, Vodnala SK, Clever D

Nature
537 1476-4687:539-543 (2016)

PMID: 27626381

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

Clever D, Roychoudhuri R, Constantinides MG

Cell
166 1097-4172:1117-1131.e14 (2016)

PMID: 27565342

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.

Roychoudhuri R, Clever D, Li P

Nature immunology
1529-2916: (2016)

PMID: 27158840

The transcription factor BACH2 promotes tumor immunosuppression.

Roychoudhuri R, Eil RL, Clever D

The Journal of clinical investigation
1558-8238: (2016)

PMID: 26731475

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

Sukumar M, Liu J, Mehta GU

Cell metabolism
1932-7420: (2015)

PMID: 26674251

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.

Klebanoff CA, Scott CD, Leonardi AJ

The Journal of clinical investigation
1558-8238: (2015)

PMID: 26657860

Oncogenic PI3Kα promotes multipotency in breast epithelial cells.

Okkenhaug K, Roychoudhuri R

Science signaling
8 1937-9145:pe3 (2015)

PMID: 26535006

Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape.

Crompton JG, Narayanan M, Cuddapah S

Cellular & molecular immunology
2042-0226: (2015)

PMID: 25914936

The interplay of effector and regulatory T cells in cancer.

Roychoudhuri R, Eil RL, Restifo NP

Current opinion in immunology
33C 1879-0372:101-111 (2015)

PMID: 25728990

Super-enhancers delineate disease-associated regulatory nodes in T cells.

Vahedi G, Kanno Y, Furumoto Y

Nature
1476-4687: (2015)

PMID: 25686607