Life Sciences Research for Lifelong Health


Rahul studied Natural Sciences and Medicine at the University of Cambridge and then Clinical Medicine at Guy's, King's and St. Thomas' Hospitals in London. Rahul's interest in the transcriptional regulation of T cell differentiation developed during his doctoral and postdoctoral research at the US National Institute of Allergy and Infectious Diseases, investigating heterogeneity in gene expression within single immune cells responding to infection. His later postdoctoral work at the US National Cancer Institute explored mechanisms by which transcriptional programmes are regulated by transcription factors within lymphocytes. His findings have extended our understanding of how transcription factors control gene expression to control the outcome of immune responses in physiology and infection, and how cancers co-opt mechanisms of immunological tolerance to drive immunosuppression. 

Rahul's group at the Babraham Institute focuses on mechanisms that guide the differentiation, stability and function of T cells under physiological conditions and during chronic infections, and cancer. Current research projects in the lab explore how transcription factors are regulated by extrinsic signals, how they interact at regulatory elements to achieve contextual control of gene expression, and they may be targeted to manipulate immunity during autoimmunity, chronic infections and cancer.