Life Sciences Research for Lifelong Health

Martin Turner

Research Summary

The molecular processes which control the development and function of lymphocytes have been extensively studied from the perspective of cell surface receptors and their associated intracellular signalling.

Also, many transcription factors which repress or promote the production of mRNA have been identified as being essential for lymphocyte development and activation.  These studies have revealed that genes, molecules and pathways that are used early in the development of lymphocytes are re-used in fully mature cells as part of the response to infection.

We are developing tools for measuring gene expression in rare cell populations.  We also use genome wide approaches to study RNA turnover and translation and to identify the targets of RNA binding proteins.

We aim to characterise fundamental mechanisms controlling lymphocyte development and function throughout the life-course.  These include understanding the roles of RNA binding proteins in lymphocyte development and activation. 

In the future explaining how these are integrated with signal transduction pathways, microRNA and transcription factor networks will be an important step towards a systems level understanding of immunity.

Key Publications

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.
Galloway A, Saveliev A, Łukasiak S, Hodson DJ, Bolland D, Balmanno K, Ahlfors H, Monzón-Casanova E, Mannurita SC, Bell LS, Andrews S, Díaz-Muñoz MD, Cook SJ, Corcoran A, Turner M.
Science (New York, N.Y.), 352, 1095-9203, 453-9, 2016
Abstract          Reprint          Full Text

The RNA-binding protein HuR is essential for the B cell antibody response.
Diaz-Muñoz MD, Bell SE, Fairfax K, Monzon-Casanova E, Cunningham AF, Gonzalez-Porta M, Andrews SR, Bunik VI, Zarnack K, Curk T, Heggermont WA, Heymans S, Gibson GE, Kontoyiannis DL, Ule J, Turner M
Nature Immunology, 16, 1529-2916, 415-25, 2015
PMID: 25706746

The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation.
Lu D, Nakagawa R, Lazzaro S, Staudacher P, Abreu-Goodger C, Henley T, Boiani S, Leyland R, Galloway A, Andrews S, Butcher G, Nutt SL, Turner M, Vigorito E
The Journal of Experimental Medicine, 211, 1540-9538, 2183-98, 2014
PMID: 25288398

Noncoding RNA and its associated proteins as regulatory elements of the immune system.
M Turner, A Galloway, E Vigorito
Nature Immunology, 15, 6, 484-91, 2014
PMID: 24840979

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Latest Publications

The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation.

Tiedje C, Diaz-Muñoz MD, Trulley P

Nucleic acids research
1362-4962: (2016)

PMID: 27220464

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.

Galloway A, Saveliev A, Łukasiak S

Science (New York, N.Y.)
352 1095-9203:453-9 (2016)

PMID: 27102483

MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis.

Nakagawa R, Leyland R, Meyer-Hermann M

The Journal of clinical investigation
1558-8238: (2015)

PMID: 26657861

GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.

Webb LM, Datta P, Bell SE

Journal of immunology (Baltimore, Md. : 1950)
1550-6606: (2015)

PMID: 26621859

Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation.

Tan LY, Whitfield P, Llorian M

Nucleic acids research
1362-4962: (2015)

PMID: 25940628

The RNA-binding protein HuR is essential for the B cell antibody response.

Diaz-Muñoz MD, Bell SE, Fairfax K

Nature immunology
16 1529-2916:415-25 (2015)

PMID: 25706746

Deletion of AU-Rich Elements within the Bcl2 3'UTR Reduces Protein Expression and B Cell Survival In Vivo.

Díaz-Muñoz MD, Bell SE, Turner M

PloS one
10 1932-6203:e0116899 (2015)

PMID: 25680182

PI3K Signaling in B Cell and T Cell Biology.

Okkenhaug K, Turner M, Gold MR

Frontiers in immunology
5 1664-3224:557 (2014)

PMID: 25404931

Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8.

Webb LM, Pascall JC, Hepburn L

PloS one
9 1932-6203:e110294 (2014)

PMID: 25329815

The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation.

Lu D, Nakagawa R, Lazzaro S

The Journal of experimental medicine
211 1540-9538:2183-98 (2014)

PMID: 25288398